Cross-axis adaptation improves 3D vestibulo-ocular reflex alignment during chronic stimulation via a head-mounted multichannel vestibular prosthesis.
Cross-axis adaptation improves 3D vestibulo-ocular reflex alignment during chronic stimulation via a head-mounted multichannel vestibular prosthesis.
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DOI：
10.1007/s00221-011-2591-5
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发表时间：
2011-05
影响因子：
2
通讯作者：
Della Santina, Charles C.
中科院分区：
文献类型：
--
作者：
Dai, Chenkai;Fridman, Gene Y.;Chiang, Bryce;Davidovics, Natan S.;Melvin, Thuy-Anh;Cullen, Kathleen E.;Della Santina, Charles C.
关键词：
通过感测三维（3D）头部旋转和电刺激前庭神经的三个壶腹分支以编码头部角速度，多通道前庭假体（MVP）可以恢复因前庭毛细胞功能丧失而残疾的个体的前庭感觉。然而，电流传播到支配非目标管道和耳石终末器官的传入纤维会扭曲前庭神经激活模式，导致感知和实际头部旋转轴之间的不对准。我们假设，随着时间的推移，中枢神经机制可以适应纠正这种错位。为了测试这一点，我们通过双侧庆大霉素治疗使5只栗鼠前庭缺陷，并将头戴式MVP单侧植入它们。在连续使用MVP的第一、第三和第七天，在黑暗中2 Hz、50°/s峰值水平正弦头部旋转期间的3D角前庭眼反射（aVOR）反应的比较显示，在假体刺激的一周结束时，关于预期轴的眼睛反应保持稳定（约为正常增益的70%），而未对准显著改善。一个相当的时间过程中的改善也观察到头部旋转的其他两个半规管轴，并在每个刺激频率检查（0.2-5赫兹）。此外，在同一时间窗内，双眼之间的不共轭程度逐渐改善。这些结果表明，中枢神经系统迅速适应多通道人工前庭刺激，在激活后的第一周内显著改善3D aVOR对准。类似的适应性改善可能发生在其他物种中，包括人类。
By sensing three-dimensional (3D) head rotation and electrically stimulating the three ampullary branches of a vestibular nerve to encode head angular velocity, a multichannel vestibular prosthesis (MVP) can restore vestibular sensation to individuals disabled by loss of vestibular hair cell function. However, current spread to afferent fibers innervating non-targeted canals and otolith endorgans can distort the vestibular nerve activation pattern, causing misalignment between the perceived and actual axis of head rotation. We hypothesized that over time, central neural mechanisms can adapt to correct this misalignment. To test this, we rendered five chinchillas vestibular-deficient via bilateral gentamicin treatment and unilaterally implanted them with a head mounted MVP. Comparison of 3D angular vestibulo-ocular reflex (aVOR) responses during 2 Hz, 50°/s peak horizontal sinusoidal head rotations in darkness on the first, third and seventh days of continual MVP use revealed that eye responses about the intended axis remained stable (at about 70% of the normal gain) while misalignment improved significantly by the end of one week of prosthetic stimulation. A comparable time course of improvement was also observed for head rotations about the other two semicircular canal axes and at every stimulus frequency examined (0.2–5 Hz). In addition, the extent of disconjugacy between the two eyes progressively improved during the same time window. These results indicate that the central nervous system rapidly adapts to multichannel prosthetic vestibular stimulation to markedly improve 3D aVOR alignment within the first week after activation. Similar adaptive improvements are likely to occur in other species, including humans.
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DOI：
10.1007/s10162-010-0208-5
发表时间：
2010-09-01
影响因子：
2.4
作者：
Fridman, Gene Y.;Davidovics, Natan S.;Della Santina, Charles C.
通讯作者：
Della Santina, Charles C.
影响因子：
3.8
作者：
Gong, WS;Merfeld, DM
通讯作者：
Merfeld, DM
DOI：
10.1016/0957-4271(94)00026-x
发表时间：
1995-03-01
期刊：
Journal of vestibular research : equilibrium & orientation
影响因子：
--
作者：
Curthoys, I S;Halmagyi, G M
通讯作者：
Halmagyi, G M
影响因子：
2.5
作者：
BAIRD, RA;DESMADRYL, G;GOLDBERG, JM
通讯作者：
GOLDBERG, JM
影响因子：
9.9
作者：
Cremer, PD;Minor, LB;Della Santina, CC
通讯作者：
Della Santina, CC