Functional dysconnectivity and microstructural impairment of the cortico-thalamo-cortical network in women with rheumatoid arthritis: A multimodal MRI study.
Functional dysconnectivity and microstructural impairment of the cortico-thalamo-cortical network in women with rheumatoid arthritis: A multimodal MRI study.
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女性类风湿关节炎患者皮质-丘脑-皮质网络的功能性连接障碍和微结构损伤：一项多模式MRI研究
DOI：
10.1016/j.heliyon.2024.e24725
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发表时间：
2024-01-30
期刊：
影响因子：
4
通讯作者：
Ma, Shuhua
中科院分区：
文献类型：
--
作者：
Zheng, Yanmin;Xie, Lei;Huang, Zikai;Peng, Jianhua;Huang, Shuxin;Guo, Ruiwei;Huang, Jinzhuang;Lin, Zhirong;Zhuang, Zelin;Yin, Jingjing;Hou, Zhiduo;Ma, Shuhua
认知缺陷在类风湿关节炎（RA）患者中较为常见，但其机制尚不清楚。我们对存在认知障碍的RA患者核心脑区的有效连接性及结构改变进行了研究。
研究招募了24名女性RA患者和24名健康对照者。我们利用功能磁共振成像（fMRI）分析在爱荷华赌博任务（IGT）期间的异常脑活动模式，并运用动态因果模型（DCM）分析核心脑区的有效连接性。通过基于体素的形态学测量（VBM）检测白质体积（WMV）和灰质体积（GMV）的结构改变。
RA患者表现出皮质 - 丘脑 - 皮质网络的激活模式改变，从左侧腹内侧前额叶回至前扣带回皮质（ACC）、从ACC至右侧丘脑的耦合强度增加，而从丘脑至左侧海马体的连接性降低。VBM结构分析显示，RA患者双侧眶额叶回、双侧海马体和右侧壳核的GMV增加，双侧丘脑的GMV和WMV减少。右侧丘脑的GMV和WMV与右侧丘脑至海马体的连接强度呈正相关。此外，RA患者右侧丘脑的血氧水平依赖（BOLD）信号、GMV和WMV与认知表现（IGT得分）呈正相关。
研究结果表明，RA患者的皮质 - 丘脑 - 皮质网络存在结构和功能缺陷，其特征为ACC至丘脑的连接强度增加以及丘脑至海马体的耦合降低。认知功能障碍可能是针对皮质 - 丘脑 - 皮质耦合失衡所采取的代偿措施的结果。
目前的数据支持这样一种观点，即患类风湿关节炎的女性可能在皮质 - 丘脑 - 皮质网络的结构和功能方面存在缺陷。2. 皮质 - 丘脑 - 皮质系统的变化可能对类风湿关节炎患者所表现出的认知缺陷产生主要影响，这可能导致女性RA患者决策能力受损。
Cognitive deficits are common in rheumatoid arthritis (RA) patients, but the mechanisms remain unclear. We investigated the effective connectivity and structural alterations of the core brain regions in RA patients with cognitive impairment. Twenty-four female patients with RA and twenty-four healthy controls were enrolled. We analyzed abnormal brain activity patterns using functional MRI during the Iowa gambling task (IGT) and core regions effective connectivity using dynamic causal model (DCM). Structural alterations of white matter volume (WMV) and gray matter volume (GMV) were detected using voxel-based morphometry (VBM). RA patients showed altered activation patterns of the cortico-thalamo-cortical network, increased coupling strength from the left ventromedial prefrontal gyrus to the anterior cingulate cortex (ACC), the ACC to the right thalamus, and decreased connectivity from the thalamus to left hippocampus. VBM structural analysis showed increased GMV in the bilateral orbital frontal gyrus, bilateral hippocampus and right putamen, and reduced GMV and WMV in the bilateral thalamus in RA patients. Right thalamic GMV and WMV were positively correlated with the right thalamus-to-hippocampus connective strength. Additionally, the bold signal, GMV and WMV of the right thalamus were positively correlated with cognitive performance (IGT score) in RA patients. Results suggest a structural and functional deficiency in the cortico-thalamo-cortical network, which is characterized by increased ACC-to-thalamus strength and reduced thalamus-to-hippocampus coupling in RA patients. The cognitive dysfunction may be the result of compensatory measures against imbalanced cortico-thalamic-cortical coupling. The current data supports the idea that women with rheumatoid arthritis may have a deficiency in the structural and functional cortico-thalamo-cortical network.2. Changes in the cortico-thalamo-cortical system might have a primary impact on the cognitive deficiencies observed in rheumatoid arthritis, potentially contributing to impaired decision-making abilities among female patients with RA.
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影响因子：
13.3
作者：
Kaplan, Chelsea M.;Schrepf, Andrew;Basu, Neil
通讯作者：
Basu, Neil
DOI：
10.1196/annals.1390.022
发表时间：
2007-01-01
期刊：
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子：
--
作者：
O'Doherty, John P.;Hampton, Alan;Kim, Hackjin
通讯作者：
Kim, Hackjin
影响因子：
2.8
作者：
Farrar DC;Mian AZ;Budson AE;Moss MB;Killiany RJ
通讯作者：
Killiany RJ
影响因子：
19.9
作者：
Pergola G;Danet L;Pitel AL;Carlesimo GA;Segobin S;Pariente J;Suchan B;Mitchell AS;Barbeau EJ
通讯作者：
Barbeau EJ
影响因子：
--
作者：
Guillery RW;Sherman SM
通讯作者：
Sherman SM