The Regulatory Role of the Human Mediodorsal Thalamus.
The Regulatory Role of the Human Mediodorsal Thalamus.
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DOI：
10.1016/j.tics.2018.08.006
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发表时间：
2018-11
影响因子：
19.9
通讯作者：
Barbeau EJ
中科院分区：
文献类型：
--
作者：
Pergola G;Danet L;Pitel AL;Carlesimo GA;Segobin S;Pariente J;Suchan B;Mitchell AS;Barbeau EJ
迄今为止，人类丘脑内侧核（MD）的功能在特定的认知过程和任务方面尚未有明确的定义。尽管最初提出它在长期记忆中发挥作用，但最近对动物和人类的一系列研究揭示了它在多种认知功能中的更复杂、更广泛的作用。 MD 似乎与前额皮质和其他皮质和皮质下大脑区域一起在高级认知功能中发挥着多方面的作用。具体来说，我们建议 MD 参与皮质网络的调节，特别是当需要维持和时间扩展额叶区域持续活动模式时。丘脑内侧核与多种神经和精神疾病中观察到的认知缺陷有关。人们长期以来一直相信丘脑内侧核主要在长期记忆中发挥作用，现在正在重新考虑。最近的研究强调了它在许多与前额皮质相关的认知任务中的功能。丘脑内侧核是快速、准确地执行认知任务所必需的，并暂时扩展涉及前额皮质的皮质网络的效率。我们提出，来自人类研究的多种证据的共同点表明丘脑内侧核在调节前额叶活动模式中的作用。这些假设可以通过开发特定的神经心理学任务、用高分辨率 MRI 包裹丘脑以及使用人类颅内记录来测试。
The function of the human mediodorsal thalamic nucleus (MD) has so far eluded a clear definition in terms of specific cognitive processes and tasks. Although it was at first proposed to play a role in long-term memory, a set of recent studies in animals and humans has revealed a more complex, and broader, role in several cognitive functions. The MD seems to play a multifaceted role in higher cognitive functions together with the prefrontal cortex and other cortical and subcortical brain areas. Specifically, we propose that the MD is involved in the regulation of cortical networks especially when the maintenance and temporal extension of persistent activity patterns in the frontal lobe areas are required. The mediodorsal thalamic nucleus is involved in the cognitive deficits observed in several neurological and psychiatric disorders. The long-standing belief in a role of the mediodorsal thalamic nucleus mainly in long-term memory is now being reconsidered. Recent studies emphasize its function in many cognitive tasks related to the prefrontal cortex. The mediodorsal thalamic nucleus is required for the rapid and accurate performance of cognitive tasks and temporally extends the efficiency of cortical networks involving the prefrontal cortex. We propose that the common ground of multiple lines of evidence from human studies points to a role of the mediodorsal thalamic nucleus in regulating prefrontal activity patterns. These hypotheses can be tested by developing specific neuropsychological tasks, parceling the thalamus with high-resolution MRI, and using intracranial recordings in humans.
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影响因子：
5.7
作者：
Bartra, Oscar;McGuire, Joseph T.;Kable, Joseph W.
通讯作者：
Kable, Joseph W.
梗塞后的丘脑性健忘症：乳腺丘脑和中型核的作用。
影响因子：
9.9
作者：
Danet L;Barbeau EJ;Eustache P;Planton M;Raposo N;Sibon I;Albucher JF;Bonneville F;Peran P;Pariente J
通讯作者：
Pariente J
影响因子：
2.6
作者：
Carlesimo, G. A.;Costa, A.;Caltagirone, C.
通讯作者：
Caltagirone, C.
影响因子：
3.7
作者：
Browning, Philip G. F.;Chakraborty, Subhojit;Mitchell, Anna S.
通讯作者：
Mitchell, Anna S.
影响因子：
2.9
作者：
Balleine, Bernard W.;Morris, Richard W.;Leung, Beatrice K.
通讯作者：
Leung, Beatrice K.