Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states.

Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states.
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DOI:
10.1016/j.neuron.2021.08.036
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发表时间:
2021-11-17
期刊:
影响因子:
16.2
通讯作者:
Andermann ML
Andermann ML
中科院分区:
医学1区
文献类型:
--
作者:
Livneh Y;Andermann ML

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我们的健康依赖于我们的大脑和身体之间的持续互动:不同的器官将其当前状态传递给大脑,并反过来受到来自大脑的内脏命令以及进食,饮水,趋热性和捕食者逃逸等行为的调节。人类神经影像学和理论研究表明,岛叶皮层的预测处理在指导这些努力以维持身体内稳态方面发挥着关键作用。在这里,我们回顾了最近的研究记录和操纵啮齿动物岛叶皮层细胞活动的时间尺度从秒到小时。我们认为,考虑这些研究结果的预测处理的背景下,未来的身体状态可能会调和几个明显的差异,并提供一个统一的,启发式的模型,指导未来的工作。Livneh和Andermann回顾了最近关于岛叶皮层细胞活动的研究,时间尺度从几秒到几小时。他们在未来身体状态的预测处理背景下讨论这些发现,为指导未来的工作提供模型。
Our wellness relies on continuous interactions between our brain and body: different organs relay their current state to the brain and are regulated, in turn, by descending visceromotor commands from our brain and by actions such as eating, drinking, thermotaxis, and predator escape. Human neuroimaging and theoretical studies suggest a key role for predictive processing in insular cortex in guiding these efforts to maintain bodily homeostasis. Here, we review recent studies recording and manipulating cellular activity in rodent insular cortex at timescales from seconds to hours. We argue that consideration of these findings in the context of predictive processing of future bodily states may reconcile several apparent discrepancies and offer a unifying, heuristic model for guiding future work. Livneh and Andermann review recent studies of cellular activity in insular cortex at timescales from seconds to hours. They discuss these findings in the context of predictive processing of future bodily states to provide a model for guiding future work.
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