Protective role of nano-selenium-enriched Bifidobacterium longum in delaying the onset of streptozotocin-induced diabetes
Protective role of nano-selenium-enriched Bifidobacterium longum in delaying the onset of streptozotocin-induced diabetes
复制标题
纳米富硒长双歧杆菌对延缓链脲佐菌素诱导的糖尿病发病的保护作用。
DOI：
10.1098/rsos.181156
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发表时间：
2018-12
影响因子：
3.5
通讯作者：
Hua Zichun
中科院分区：
文献类型：
--
作者：
Lin Yan;Ren Yongzhe;Zhang Yan;Zhou Junjie;Zhou Feng;Zhao Quan;Xu Genxing;Hua Zichun
长双歧杆菌（b.l ungum）能以硒- b的形式积累硒和纳米硒。和纳米硒- b。分别longum。在本研究中，纳米硒b的作用。对糖尿病小鼠的长牙龈进行了评价。评估血糖、体重、血清胰岛素水平、腹腔葡萄糖耐量试验（IPGTT）、摄食量、饮水量和尿量等生理代谢指标。western blotting检测胰岛素信号通路相关蛋白的表达。采用血红素和伊红（H&E）对肝脏、胰腺和肾脏切片进行组织学检查。测定血清肌酐（SCr）和血尿素氮（BUN）水平。Nano-Se-B。Longum在延缓糖尿病发病方面是最好的。Nano-Se-B。与模型组相比，Longum降低了血糖和体重。与所有纳米硒b组相比，模型组大鼠IPGTT、摄食量、饮水量和尿量显著升高，血清胰岛素水平显著降低。longum-treated老鼠。组织学结果显示，纳米se - b。在病理变化方面，长时间给药小鼠明显优于模型组小鼠。胰岛素信号通路相关蛋白在纳米硒b中表达上调。longum-treated组。模型组SCr和BUN水平显著升高。本研究首次报道了纳米硒b的剂量依赖性预防作用。长牙对糖尿病的发病及肾损害。其机制可能与胰岛素信号的改变有关。
Bifidobacterium longum (B. longum) could accumulate Selenium (Se) and nano-Se in the form of Se-B. longum and Nano-Se-B. longum, respectively. In this study, the effect of Nano-Se-B. longum in diabetic mice was evaluated. Physiological and metabolic parameters such as blood glucose, body weight, serum insulin level, intraperitoneal glucose tolerance test (IPGTT), food intake, water consumption and urine output were evaluated. The expression of insulin signalling pathway-related proteins was evaluated by western blotting. Haematoxylin and eosin (H&E) was used for histological examination of the liver, pancreas and kidney sections. Creatinine levels in serum (SCr) and blood urea nitrogen (BUN) were measured. Nano-Se-B. longum was the best in terms of delaying the onset of diabetes. Nano-Se-B. longum decreased blood glucose and body weight compared with those noted for the model group. IPGTT, food intake, water consumption and urine output significantly increased and serum insulin levels significantly decreased in the model group compared with those in all the Nano-Se-B. longum-treated mice. Histological results showed that the Nano-Se-B. longum-treated mice were better than the model group mice in terms of pathological changes. The expression of insulin signalling pathway-related proteins was upregulated in the Nano-Se-B. longum-treated groups. A significant increase in SCr and BUN levels was noted in the model group. This study for the first time reported the dose-dependent preventive effect of Nano-Se-B. longum on the onset of diabetes and renal damage. The mechanism may be related to changes in insulin signalling.
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影响因子：
2.9
作者：
T. Xu;B. Yuan;Ya-Min Zou;W. Zang
通讯作者：
T. Xu;B. Yuan;Ya-Min Zou;W. Zang
DOI：
10.1016/j.fct.2003.08.002
发表时间：
2004
期刊：
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
影响因子：
--
作者：
J. Perottoni;O. Rodrigues;M. Paixão;G. Zeni;L. P. Lobato;A. Braga;J. Rocha;T. Emanuelli
通讯作者：
J. Perottoni;O. Rodrigues;M. Paixão;G. Zeni;L. P. Lobato;A. Braga;J. Rocha;T. Emanuelli
影响因子：
5.7
作者：
Li-ping Zhu;Yan Yin;Jing Xing;Chen Li;L. Kou;Bi Hu;Zhi-wei Wu;Jian-jun Wang;Gen-xing Xu
通讯作者：
Li-ping Zhu;Yan Yin;Jing Xing;Chen Li;L. Kou;Bi Hu;Zhi-wei Wu;Jian-jun Wang;Gen-xing Xu
DOI：
10.5061/dryad.8mc79/19
发表时间：
2014-08
期刊：
--
影响因子：
--
作者：
B. Mimee;Marc‐Olivier Duceppe;Pierre-Yves Véronneau;Joël Lafond-Lapalme;Martine Jean;François Belzile
通讯作者：
B. Mimee;Marc‐Olivier Duceppe;Pierre-Yves Véronneau;Joël Lafond-Lapalme;Martine Jean;François Belzile
影响因子：
3.7
作者：
Eid S;Maalouf R;Jaffa AA;Nassif J;Hamdy A;Rashid A;Ziyadeh FN;Eid AA
通讯作者：
Eid AA