Various neurocognitive deficits and conversion risk in individuals at clinical high risk for psychosis.
Various neurocognitive deficits and conversion risk in individuals at clinical high risk for psychosis.
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DOI：
10.1111/eip.12296
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发表时间：
2017-06
影响因子：
2
通讯作者：
Girgis RR
中科院分区：
文献类型：
--
作者：
Mourik K;Decrescenzo P;Brucato G;Gill KE;Arndt L;Kimhy D;Keilp JG;Girgis RR
精神病临床高危个体在多个领域表现出神经认知缺陷。本研究的目的是调查是否有几个组成部分的神经认知是预测转换为精神病。对52名精神病患者进行了精神病风险综合征结构化访谈评估，并在基线时完成了一系列神经认知测试，包括执行功能、注意力、工作记忆、处理速度和反应时间的测量。基于外部规范对照组对基线时的神经认知功能进行评分。大多数受试者随访2.5年，以确定转换状态。神经认知功能的显着差异，个体和对照组之间存在于所有领域。26%的参与者在平均9.8（标准差=8.0）个月（中位数9个月）内转化为精神病，但神经认知转化者和非转化者之间没有显著差异。处于抑郁状态的个体在神经认知功能方面存在缺陷，但这种缺陷似乎与转换风险无关。
Individuals at clinical high risk for psychosis (CHR) exhibit neurocognitive deficits in multiple domains. The aim of this study is to investigate whether several components of neurocognition are predictive of conversion to psychosis. Fifty-two CHR individuals were assessed with the Structured Interview for Psychosis Risk Syndromes and completed a battery of neurocognitive tests at baseline including measures of executive functioning, attention, working memory, processing speed, and reaction time. Neurocognitive functioning at baseline was scored based on an external normative control group. Most subjects were followed for 2.5 years to determine conversion status. Significant differences in neurocognitive functioning between CHR individuals and the control group were present in all domains. Twenty-six percent of the participants converted to psychosis within 9.8 (standard deviation=8.0) months on average (median 9 months), but there were no significant differences in neurocognition converters and non-converters. Individuals at CHR have deficits in neurocognitive functioning, but such deficits do not appear to be related to conversion risk.
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DOI：
10.1176/appi.ajp.2011.10081209
发表时间：
2011-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Carrión RE;Goldberg TE;McLaughlin D;Auther AM;Correll CU;Cornblatt BA
通讯作者：
Cornblatt BA
精神病高风险状态：全面的最新评论。
影响因子：
25.8
作者：
Fusar-Poli, Paolo;Borgwardt, Stefan;Bechdolf, Andreas;Addington, Jean;Riecher-Rossler, Anita;Schultze-Lutter, Frauke;Keshavan, Matcheri;Wood, Stephen;Ruhrmann, Stephan;Seidman, Larry J.;Valmaggia, Lucia;Cannon, Tyrone;Velthorst, Eva;De Haan, Lieuwe;Cornblatt, Barbara;Bonoldi, Ilaria;Birchwood, Max;McGlashan, Thomas;Carpenter, William;McGorry, Patrick;Klosterkotter, Joachim;McGuire, Philip;Yung, Alison
通讯作者：
Yung, Alison
影响因子：
4.5
作者：
Niendam, Tara A.;Bearden, Carrie E.;Cannon, Tyrone D.
通讯作者：
Cannon, Tyrone D.
影响因子：
6.6
作者：
Miller, TJ;McGlashan, TH;Woods, SW
通讯作者：
Woods, SW
影响因子：
--
作者：
Seidman, Larry J.;Giuliano, Anthony J.;Meyer, Eric C.;Addington, Jean;Cadenhead, Kristin S.;Cannon, Tyrone D.;McGlashan, Thomas H.;Perkins, Diana O.;Tsuang, Ming T.;Walker, Elaine F.;Woods, Scott W.;Bearden, Carrie E.;Christensen, Bruce K.;Hawkins, Keith;Heaton, Robert;Keefe, Richard S. E.;Heinssen, Robert;Cornblatt, Barbara A.
通讯作者：
Cornblatt, Barbara A.