The Effects of LIT and MLR-Bf on Immune Biomarkers and Pregnancy Outcomes in Women With Previous Early Recurrent Miscarriage: A Retrospective Study.
The Effects of LIT and MLR-Bf on Immune Biomarkers and Pregnancy Outcomes in Women With Previous Early Recurrent Miscarriage: A Retrospective Study.
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LIT 和 MLR-Bf 对既往早期复发性流产妇女免疫生物标志物和妊娠结局的影响：一项回顾性研究
DOI：
10.3389/fimmu.2021.642120
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发表时间：
2021
影响因子：
7.3
通讯作者：
Hui C
中科院分区：
文献类型：
--
作者：
Meng L;Tan J;Du T;Lin X;Zhang S;Nie X;Xie H;Lin J;Zhang J;Hui C
背景：妊娠期免疫功能衰竭被认为是复发性流产（RM）的病因之一。混合淋巴细胞反应阻断因子（MLR-Bf）的产生减少可能在这种情况下发挥重要作用。自1984年以来，诱导MLR-Bf产生的淋巴细胞免疫疗法（LIT）已用于治疗RM患者。然而，LIT的有效性目前正在激烈辩论。除此之外，LIT诱导MLR-Bf产生后母体免疫系统的可能变化仍不清楚。目的：探讨MLR-Bf对免疫生物标志物表达和妊娠结局的可能影响，并推断在RM患者中使用LIT或MLR-Bf是否可能预防流产。材料与方法：回顾性研究既往早期RM（eRM）患者再次妊娠后的情况。LIT在怀孕前和怀孕前三个月期间实施。作为临床常规检查MLR-Bf和免疫生物标志物。患者随访至12孕周。比较了MLR-Bf−组和MLR-Bf+组的免疫生物标志物水平和成功妊娠率，并估计了LIT或MLR-Bf与流产之间的独立相关性。所有数据管理和分析均采用SPSS 20.0进行。结果：共有1，038例患者，497例MLR-Bf-（49例接受LIT）和541例MLR-Bf+（463例由LIT诱导）被纳入研究。淋巴细胞百分比、CD 4 + T细胞/淋巴细胞比率和某些类风湿生物标志物水平在未接受LIT治疗的女性中，MLR-Bf+组的抗U1-nRNP、抗SAA-52 kd和抗CENOP B抗体水平在统计学上高于MLR-Bf−组。在接受LIT治疗的情况下，MLR-Bf+组的成功妊娠率在统计学上高于MLR-Bf−组（66.7%vs51.0%，P = 0.028），同时LIT与流产呈独立负相关。总结：LIT治疗后，有和无MLR-Bf的妇女的免疫生物标志物水平是不同的，当按是否接受LIT分层时。不是MLR-Bf，而是LIT，对流产有独立的保护作用。
Background: Immunological failure during pregnancy is considered one of the etiologies of recurrent miscarriage (RM). The decreased production of mixed lymphocyte reaction-blocking factors (MLR-Bf) may play a major role in this condition. Lymphocyte immunotherapy (LIT), which induces the production of MLR-Bf, has been used in treating RM patients since 1984. However, the effectiveness of LIT is currently being heatedly debated. In addition to that, possible changes to the maternal immune system upon induced MLR-Bf production by LIT remains unclear. Objectives: To explore the possible impacts that MLR-Bf may have on the expression of immune biomarkers and pregnancy outcomes, and deduce whether the prevention of miscarriages is possible with LIT or MLR-Bf in RM patients. Materials and Methods: Women with previous early RM (eRM) were enrolled in this retrospective study after they got pregnant again. LIT was implemented before pregnancy and during the first trimester. MLR-Bf and immune biomarkers were checked as the clinical routine. Patients were followed up until 12 gestational weeks. Levels of immune biomarkers and successful pregnancy rates were compared between MLR-Bf− group and MLR-Bf+ group stratified by LIT. Independent associations between LIT, or MLR-Bf, and miscarriage were estimated. All data management and analysis were conducted using SPSS 20.0. Results: A total of 1,038 patients, 497 MLR-Bf− (49 cases accepted LIT), and 541 MLR-Bf+(463 cases induced by LIT) were included in the study. Percentage of lymphocytes, the ratio of CD4+ T cells/lymphocytes, and levels of some rheumatoid biomarkers (anti-U1-nRNP, anti-SAA-52kd, and anti-CENOP B) were statistically higher in MLR-Bf+ group than in MLR-Bf− group among women without LIT. With LIT treatment the successful pregnancy rate was statistically higher in MLR-Bf+ group than in MLR-Bf− group (66.7% vs. 51.0%, P = 0.028) among women with LIT. Meanwhile, LIT was estimated to have an independent negative association with miscarriage. Conclusion: Upon LIT treament levels of immune biomarkers were different in women with and without MLR-Bf when stratified by whether they received LIT. Not MLR-Bf, but LIT, has an independent protective effect on miscarriage.
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影响因子：
3.1
作者：
Pandey MK;Saxena V;Agrawal S
通讯作者：
Agrawal S
DOI：
10.1080/14767058.2017.1334048
发表时间：
2018-01-01
影响因子：
1.8
作者：
Iijima, Shigeo
通讯作者：
Iijima, Shigeo
DOI：
10.1111/j.1600-0897.2007.00529.x
发表时间：
2007-11-01
影响因子：
3.6
作者：
van den Heuvel, Marianne J.;Peralta, Crystal G.;Clark, David A.
通讯作者：
Clark, David A.
DOI：
10.3109/13625187.2015.1046593
发表时间：
2015-11-02
影响因子：
1.7
作者：
Xu, Liang;Qiu, Tian;Lin, Qide
通讯作者：
Lin, Qide
DOI：
10.1111/j.1600-0897.2010.00863.x
发表时间：
2010-12-01
影响因子：
3.6
作者：
Ticconi, Carlo;Rotondi, Federica;Di Simone, Nicoletta
通讯作者：
Di Simone, Nicoletta