Cancer theranostics: the rise of targeted magnetic nanoparticles.

Cancer theranostics: the rise of targeted magnetic nanoparticles.
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DOI:
10.1016/j.tibtech.2011.03.001
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发表时间:
2011-07
影响因子:
17.3
通讯作者:
David, Allan E.
David, Allan E.
中科院分区:
工程技术1区
文献类型:
--
作者:
Cole, Adam J.;Yang, Victor C.;David, Allan E.

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在过去的二十年中,利用磁性纳米粒子(MNP)用于生物医学应用的兴趣已经大大增长。这种兴奋在很大程度上是由MNP在磁共振成像(MRI)中作为造影剂的成功所驱动的。最近关于癌症的研究趋势继续沿着诊断路径进行,但也转向同时治疗-引起MNP作为潜在的“治疗诊断学”的区别。在这里,我们审查MNP的关键技术原则和癌症治疗诊断MNP的持续进展。最近的进展,诊断,热疗治疗,和药物输送都被认为是。最后,我们确定了目前的障碍,临床翻译的MNP和他们的未来发展提供考虑。
Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has grown considerably over the past two decades. This excitement is driven in large part by the success of MNPs as contrast agents in magnetic resonance imaging (MRI). The recent investigative trend with respect to cancer has continued down a diagnostic path, but has also turned toward concurrent therapy – giving rise to the distinction of MNPs as potential “theranostics”. Here we review both the key technical principles of MNPs and the ongoing advancement toward a cancer theranostic MNP. Recent progress in diagnostics, hyperthermia treatments, and drug delivery are all considered. We conclude by identifying current barriers to clinical translation of MNPs and offer considerations for their future development.
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