Substantiating in vivo magnetic brain tumor targeting of cationic iron oxide nanocarriers via adsorptive surface masking.
Substantiating in vivo magnetic brain tumor targeting of cationic iron oxide nanocarriers via adsorptive surface masking.
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DOI：
10.1016/j.biomaterials.2009.08.040
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发表时间：
2009-12
期刊：
影响因子：
14
通讯作者：
Yang, Victor C.
中科院分区：
文献类型：
--
作者：
Chertok, Beata;David, Allan E.;Moffat, Bradford A.;Yang, Victor C.
阳离子磁性纳米粒子由于其与肿瘤环境和治疗货物的良好相互作用而作为潜在的肿瘤药物递送载体具有吸引力。然而，这些纳米颗粒向肿瘤部位的全身递送受到其快速血浆清除的影响。我们开发了一种简单的方法，在体内保护阳离子纳米载体，使用非共价表面掩蔽与低分子量肝素和聚乙二醇的共轭物。在原位啮齿动物脑肿瘤中，表面掩蔽导致血浆AUC增加11倍，全身注射纳米颗粒的磁性捕获增加2倍。总之，所描述的方法可以扩展阳离子磁性纳米颗粒在磁介导的基因/药物递送中的应用前景。
Cationic magnetic nanoparticles are attractive as potential vehicles for tumor drug delivery due to their favorable interactions with both the tumor milieu and the therapeutic cargo. However, systemic delivery of these nanoparticles to the tumor site is compromised by their rapid plasma clearance. We developed a simple method for in vivo protection of cationic nanocarriers, using non-covalent surface masking with a conjugate of low molecular weight heparin and polyethylene glycol. Surface masking resulted in an 11-fold increase in plasma AUC and a 2-fold increase in the magnetic capture of systemically injected nanoparticles in orthotopic rodent brain tumors. Overall, the described methodology could expand the prospective applications for cationic magnetic nanoparticles in magnetically-mediated gene/drug delivery.
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影响因子：
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