Gaining insight of fetal brain development with diffusion MRI and histology.
Gaining insight of fetal brain development with diffusion MRI and histology.
复制标题
DOI：
10.1016/j.ijdevneu.2013.06.005
复制
发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Vasung L
中科院分区：
文献类型：
--
作者：
Huang H;Vasung L
人类的大脑是非常复杂的，但它的起源是一个简单的管状结构。它在胎儿时期的发展是以一系列精确组织的事件为特征的，这些事件是胎儿发育期间戏剧性结构变化机制的基础。揭示人类胎儿大脑发育不同阶段的详细解剖结构，不仅有助于了解这一高度有序的过程，还有助于了解认知性大脑障碍的神经生物学基础，如智力迟钝、自闭症、精神分裂症、双相情感障碍和语言障碍。扩散张量成像（DTI）和组织学是互补的工具，能够描绘胎儿大脑结构在宏观和微观水平。本文综述了应用DTI技术和组织学方法对胎儿脑结构发育的研究进展。利用DTI技术和组织学方法，对胎儿脑的主要组成部分，包括皮质板、胎儿白色物质和脑室与基板之间的脑壁层进行了描述。利用DTI技术获得的各向异性指标，对人胎儿大脑皮层发育动态过程中的微结构变化进行了定量研究，并对其他动物模型的产前发育进行了研究。胎儿白色物质通路已被跟踪与DTI为基础的纤维束成像，以揭示个别白色物质束和皮质连接的生长模式。这些详细的解剖学描述的结构变化在胎儿时期可能提供线索，发现在其早期阶段的发育和认知脑障碍。DTI和组织学的解剖学信息也可为早产儿的放射诊断提供参考标准。
Human brain is extraordinarily complex and yet its origin is a simple tubular structure. Its development during the fetal period is characterized by a series of accurately organized events which underlie the mechanisms of dramatic structural changes during fetal development. Revealing detailed anatomy at different stages of human fetal brain development provides insight on understanding not only this highly ordered process, but also the neurobiological foundations of cognitive brain disorders such as mental retardation, autism, schizophrenia, bipolar and language impairment. Diffusion tensor imaging (DTI) and histology are complementary tools which are capable of delineating the fetal brain structures at both macroscopic and microscopic level. In this review, the structural development of the fetal brains has been characterized with DTI and histology. Major components of the fetal brain, including cortical plate, fetal white matter and cerebral wall layer between the ventricle and subplate, have been delineated with DTI and histology. Anisotropic metrics derived from DTI were used to quantify the microstructural changes during the dynamic process of human fetal cortical development and prenatal development of other animal models. Fetal white matter pathways have been traced with DTI-based tractography to reveal growth patterns of individual white matter tracts and corticocortical connectivity. These detailed anatomical accounts of the structural changes during fetal period may provide the clues of detecting developmental and cognitive brain disorders at their early stages. The anatomical information from DTI and histology may also provide reference standards for diagnostic radiology of premature newborns.
登录
查看更多内容
影响因子：
19.7
作者：
CHENEVERT, TL;BRUNBERG, JA;PIPE, JG
通讯作者：
PIPE, JG
影响因子：
11.2
作者：
CHI, JG;DOOLING, EC;GILLES, FH
通讯作者：
GILLES, FH
影响因子：
8
作者：
H端ppi, PS;Murphy, B;Volpe, JJ
通讯作者：
Volpe, JJ
影响因子：
5.7
作者：
Huang, Hao;Zhang, Jiangyang;Mori, Susumu
通讯作者：
Mori, Susumu
影响因子：
3.3
作者：
HSU, EW;MORI, S
通讯作者：
MORI, S