In vivo characterization of magnetic resonance imaging-based T1w/T2w ratios reveals myelin-related changes in temporal lobe epilepsy.
In vivo characterization of magnetic resonance imaging-based T1w/T2w ratios reveals myelin-related changes in temporal lobe epilepsy.
复制标题
DOI：
10.1002/hbm.26212
复制
发表时间：
2023-04-15
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
颞叶癫痫（TLE）是成人最常见的顽固性癫痫。虽然在TLE中观察到脑髓鞘形成改变，但髓鞘形成网络如何在TLE中改变尚不清楚。本研究开发了一种利用T1加权和T2加权磁共振成像（MRI）表征髓鞘结构协方差网络（mSCN）的新方法。在42例左TLE （LTLE）、42例右TLE （RTLE）患者和41例健康对照（hc）中估计mscn。利用图论分析了mSCN的拓扑结构。三组间的髓鞘侧性体素比较也被检查。与HC相比，两组患者均表现出额颞叶区、杏仁核和丘脑髓鞘形成减少；然而，与RTLE相比，LTLE在左侧内侧颞区显示较低的髓鞘形成。此外，与HC相比，LTLE的整体效率降低，连接数比RTLE增加。两组患者的壳核侧边度有不同的变化：小tle组后壳核侧边度较高，而大tle组前壳核侧边度较高。壳核可能在癫痫发作引起的海马损伤扩散中起转运站作用。本研究首次提供了一种新颖的工作流程，通过T1加权和T2加权的MRI结合来研究癫痫患者体内髓磷脂相关的微结构特征。mSCN的断开意味着TLE是一种在区域和网络水平上广泛中断的系统紊乱。提出了一种利用T1加权和T2加权磁共振成像表征髓鞘结构协方差网络的新方法。髓鞘网络的断开提示颞叶癫痫是一种脑网络紊乱的系统疾病。
Temporal lobe epilepsy (TLE) is the most common type of intractable epilepsy in adults. Although brain myelination alterations have been observed in TLE, it remains unclear how the myelination network changes in TLE. This study developed a novel method in characterization of myelination structural covariance network (mSCN) by T1‐weighted and T2‐weighted magnetic resonance imaging (MRI). The mSCNs were estimated in 42 left TLE (LTLE), 42 right TLE (RTLE) patients, and 41 healthy controls (HCs). The topology of mSCN was analyzed by graph theory. Voxel‐wise comparisons of myelination laterality were also examined among the three groups. Compared to HC, both patient groups showed decreased myelination in frontotemporal regions, amygdala, and thalamus; however, the LTLE showed lower myelination in left medial temporal regions than RTLE. Moreover, the LTLE exhibited decreased global efficiency compared with HC and more increased connections than RTLE. The laterality in putamen was differently altered between the two patient groups: higher laterality at posterior putamen in LTLE and higher laterality at anterior putamen in RTLE. The putamen may play a transfer station role in damage spreading induced by epileptic seizures from the hippocampus. This study provided a novel workflow by combination of T1‐weighted and T2‐weighted MRI to investigate in vivo the myelin‐related microstructural feature in epileptic patients first time. Disconnections of mSCN implicate that TLE is a system disorder with widespread disruptions at regional and network levels. A novel method was developed for characterization of myelination structural covariance network by T1‐weighted and T2‐weighted magnetic resonance imaging. Disconnections of myelination network suggest that temporal lobe epilepsy is a system disorder with disrupted brain network.
登录
查看更多内容
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
3.7
作者：
Bernhardt, Boris C.;Bernasconi, Neda;Bernasconi, Andrea
通讯作者：
Bernasconi, Andrea
影响因子：
34.7
作者：
Alexander-Bloch, Aaron;Giedd, Jay N.;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
5.7
作者：
Agcaoglu O;Miller R;Mayer AR;Hugdahl K;Calhoun VD
通讯作者：
Calhoun VD
影响因子：
14.5
作者：
Guye, Maxime;Regis, Jean;Bartolomei, Fabrice
通讯作者：
Bartolomei, Fabrice