Vitamin D3 Dose Requirement That Raises 25-Hydroxyvitamin D to Desirable Level in Overweight and Obese Elderly.
Vitamin D3 Dose Requirement That Raises 25-Hydroxyvitamin D to Desirable Level in Overweight and Obese Elderly.
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DOI：
10.1210/clinem/dgab296
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发表时间：
2021-08-18
期刊：
影响因子：
--
通讯作者：
El-Hajj Fuleihan G
中科院分区：
文献类型：
--
作者：
Bacha DS;Rahme M;Al-Shaar L;Baddoura R;Halaby G;Singh RJ;Mahfoud ZR;Habib R;Arabi A;El-Hajj Fuleihan G
维生素D补充剂的剂量指南在全球范围内差异很大。 研究2种维生素D剂量（介于IOM推荐的膳食供给量（RDA）和耐受上限之间）对老年人维生素D营养状况的影响。对从一项12个月、双盲、随机对照试验中收集的数据进行事后分析，纳入了221名非卧床受试者（≥ 65岁），平均BMI为30.2 kg/m2，平均基线血清25-羟基维生素D [25（OH）D]水平为20.4 ± 7.4 ng/mL，这些受试者从黎巴嫩的3家门诊中心招募。 所有参与者每天从柠檬酸钙中接受1000 mg的元素钙，加上每天相当于600 IU或3750 IU的维生素D3。12个月时，低剂量维生素D3组的平均25（OH）D水平为26.0 ng/mL，高剂量维生素D3组为36.0 ng/mL。低剂量组达到≥ 20 ng/mL值的受试者比例为86%，高剂量组为99%，无性别差异。低剂量组每100 IU/天25（OH）D的增量为1 ng/mL，高剂量组为0.41 ng/mL。两个治疗组1年时的血清25（OH）D水平差异很大。基线25（OH）D水平和维生素D剂量-而不是年龄，BMI，性别或季节-是干预后血清25（OH）D水平的重要预测因素。IOM推荐的600 IU/天的膳食允许量（RDA）并没有使97.5%的非卧床老年人超过20 ng/mL的理想阈值。各国的RDA最好考虑到观察到的变异性和达到的25（OH）D水平的预测因素。
Guidelines for the dosage of vitamin D supplementation vary widely globally. To investigate the impact of 2 vitamin D doses, bracketed between the IOM recommended dietary allowance (RDA) and the upper tolerable limit, on vitamin D nutritional status in elderly individuals. This post hoc analysis of data collected from a 12-month, double-blind, randomized control trial included 221 ambulatory participants (≥ 65 years) with a mean BMI of 30.2 kg/m2 and a mean baseline serum 25-hydroxyvitamin D [25(OH)D] level of 20.4 ± 7.4 ng/mL, who were recruited from 3 outpatient centers in Lebanon. All participants received 1000 mg of elemental calcium daily from calcium citrate plus the daily equivalent of either 600 IU or 3750 IU of vitamin D3. Mean 25(OH)D level at 12 months was 26.0 ng/mL with low dose and 36.0 ng/mL with high dose vitamin D3. The proportion of participants reaching a value ≥ 20 ng/mL was 86% in the low dose, and 99% in the high dose arms, with no gender differences. The increment of 25(OH)D per 100 IU/day was 1 ng/mL with the low dose, and 0.41 ng/mL with the high dose. Serum 25(OH)D levels at 1 year were highly variable in both treatment arms. Baseline 25(OH)D level and vitamin D dose—but not age, BMI, gender, or season—were significant predictors of serum 25(OH)D level post-intervention. The IOM Recommended Dietary Allowance (RDA) of 600 IU/day does not bring 97.5% of ambulatory elderly individuals above the desirable threshold of 20 ng/mL. Country-specific RDAs are best derived taking into account the observed variability and predictors of achieved 25(OH)D levels.
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影响因子：
20.3
作者：
Bouillon R;Marcocci C;Carmeliet G;Bikle D;White JH;Dawson-Hughes B;Lips P;Munns CF;Lazaretti-Castro M;Giustina A;Bilezikian J
通讯作者：
Bilezikian J
影响因子：
5.8
作者：
Holick, Michael F.;Binkley, Neil C.;Weaver, Connie M.
通讯作者：
Weaver, Connie M.
DOI：
10.1016/j.beem.2011.05.002
发表时间：
2011-08-01
影响因子：
7.4
作者：
Lips, Paul;van Schoor, Natasja M.
通讯作者：
van Schoor, Natasja M.
DOI：
10.4161/derm.25111
发表时间：
2013-04-01
期刊：
Dermato-endocrinology
影响因子：
--
作者：
Bassil D;Rahme M;Hoteit M;Fuleihan Gel-H
通讯作者：
Fuleihan Gel-H
影响因子：
5.8
作者：
Ish-Shalom, Sophia;Segal, Elena;Vieth, Reinhold
通讯作者：
Vieth, Reinhold