Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder.
Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder.
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重复经颅磁刺激可改善创伤后应激障碍大鼠模型的焦虑样行为和感觉运动门控受损。
DOI：
10.1371/journal.pone.0117189
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Tan QR
中科院分区：
文献类型：
--
作者：
Wang HN;Bai YH;Chen YC;Zhang RG;Wang HH;Zhang YH;Gan JL;Peng ZW;Tan QR
重复经颅磁刺激(RTMS)作为创伤后应激障碍(PTSD)的非药物治疗方法已有数十年的历史。尽管创伤后应激障碍与感觉运动门控受损之间存在联系，但评估rTMS对创伤后应激障碍或伴有感觉运动门控受损的创伤后应激障碍的疗效的研究很少。评估rTMS在创伤后应激障碍大鼠模型中的益处。采用改良的单次持续应激(SPS&S)大鼠创伤后应激(PTSD)模型，采用旷场实验、高架迷宫实验和脉冲前抑制实验(PPI)，观察给予或不给予高频(10 HzrTMS)7d后大鼠的行为学参数。SPS和S动物在长时间应激后出现焦虑样行为，脑干皮质功能受损，血浆皮质醇水平升高。有趣的是，应激后立即给予rTMS可以防止这些损害。应激后会出现应激诱导的焦虑样行为、血浆皮质醇水平升高和PPI受损，高频rTMS有可能改善这种行为，提示高频rTMS作为一种预防PTSD的方法值得进一步评估。
Repetitive transcranial magnetic stimulation (rTMS) has been employed for decades as a non-pharmacologic treatment for post-traumatic stress disorder (PTSD). Although a link has been suggested between PTSD and impaired sensorimotor gating (SG), studies assessing the effects of rTMS against PTSD or PTSD with impaired SG are scarce. To assess the benefit of rTMS in a rat model of PTSD. Using a modified single prolonged stress (SPS&S) rat model of PTSD, behavioral parameters were acquired using open field test (OFT), elevated plus maze test (EPMT), and prepulse inhibition trial (PPI), with or without 7 days of high frequency (10Hz) rTMS treatment of SPS&S rats. Anxiety-like behavior, impaired SG and increased plasma level of cortisol were observed in SPS&S animals after stress for a prolonged time. Interestingly, rTMS administered immediately after stress prevented those impairment. Stress-induced anxiety-like behavior, increased plasma level of cortisol and impaired PPI occur after stress and high-frequency rTMS has the potential to ameliorate this behavior, suggesting that high frequency rTMS should be further evaluated for its use as a method for preventing PTSD.
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DOI：
10.4088/jcp.08m04638blu
发表时间：
2010-08
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Boggio PS;Rocha M;Oliveira MO;Fecteau S;Cohen RB;Campanhã C;Ferreira-Santos E;Meleiro A;Corchs F;Zaghi S;Pascual-Leone A;Fregni F
通讯作者：
Fregni F
影响因子：
3
作者：
Bitsios, P;Giakoumaki, SG
通讯作者：
Giakoumaki, SG
影响因子：
2.5
作者：
HERBERT, H;ASCHOFF, A;OSTWALD, J
通讯作者：
OSTWALD, J
影响因子：
2.3
作者：
Kumari, V;Gray, JA;Sharma, T
通讯作者：
Sharma, T
影响因子：
6.1
作者：
Gillette, GM;Skinner, RD;GarciaRill, E
通讯作者：
GarciaRill, E