Baseline Detrending for the Photopic Negative Response.
Baseline Detrending for the Photopic Negative Response.
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DOI：
10.1167/tvst.7.5.9
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发表时间：
2018-09
影响因子：
3
通讯作者：
Hadoux X
中科院分区：
文献类型：
--
作者：
Tang J;Hui F;Coote M;Crowston JG;Hadoux X
光适应视网膜电图（ERG）的明视负反应（PhNR）有望成为视网膜神经节细胞功能的客观标志。我们比较了基线去趋势方法，以提高PhNR的可重复性，而不影响其对青光眼的诊断能力。记录了20名青光眼患者和18名年龄匹配的对照参与者的明视ERG。使用RETeval器械在蓝色背景（10明视cd/m2）上共发出50次短暂的红色闪光（1.6 cd.s/m2）。比较的去趋势方法为：（1）将高通滤波器从1 Hz增加到10 Hz，以及（2）利用应用于刺激前间隔、刺激前和信号后间隔或整个ERG信号的递增多项式（1-10阶）来估计和去除趋势。重复性系数（COR%）、非配对Student t检验和受试者工作特征曲线下面积（AUC）用于比较去趋势方法。与国际临床视觉电生理学会（ISCEV）推荐的0.3至300 Hz带通滤波器（COR% ± 200%）相比，大多数去趋势方法改善了PhNR测试-重测重复性。特别是，应用于整个信号的多项式（3阶）去趋势表现最好（COR% ± 44%），同时实现与ISCEV带通相似的诊断能力（AUC分别为0.74 vs. 0.75）。然而，使用更高阶处理的过度校正可能导致波形失真并降低诊断能力。基线去趋势可以改善PhNR的可重复性，而不会影响其在青光眼中的临床应用。鼓励进一步研究探索更复杂的处理方法。基线去趋势可以显著提高PhNR的质量。
The photopic negative response (PhNR) of the light-adapted electroretinogram (ERG) holds promise as an objective marker of retinal ganglion cell function. We compared baseline detrending methods to improve PhNR repeatability without compromising its diagnostic ability in glaucoma. Photopic ERGs were recorded in 20 glaucoma and 18 age-matched control participants. A total of 50 brief, red-flashes (1.6 cd.s/m2) on a blue background (10 photopic cd/m2) were delivered using the RETeval device. Detrending methods compared were: (1) increasing the high-pass filter from 1 to 10 Hz and (2) estimating and removing the trend with an increasing polynomial (order from 1–10) applied to the prestimulus interval, prestimulus and postsignal interval, or the whole ERG signal. Coefficient of repeatability (COR%), unpaired Student's t-test, and area under the receiver operating characteristic curve (AUC) were used to compare the detrending methods. Most detrending methods improved PhNR test–retest repeatability compared to the International Society for Clinical Electrophysiology of Vision (ISCEV) recommended 0.3 to 300 Hz band-pass filter (COR% ± 200%). In particular, detrending with a polynomial (order 3) applied to the whole signal performed the best (COR% ± 44%) while achieving similar diagnostic ability as ISCEV band-pass (AUC 0.74 vs. 0.75, respectively). However, over-correcting with higher orders of processing can cause waveform distortion and reduce diagnostic ability. Baseline detrending can improve the PhNR repeatability without compromising its clinical use in glaucoma. Further studies exploring more complex processing methods are encouraged. Baseline detrending can significantly improve the quality of the PhNR.
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DOI：
10.1007/s10633-016-9528-z
发表时间：
2016-02
期刊：
Documenta ophthalmologica. Advances in ophthalmology
影响因子：
--
作者：
Kirkiewicz M;Lubiński W;Penkala K
通讯作者：
Penkala K
锯齿闪烁引起的晚期ERG反应的特征。
影响因子：
1.4
作者：
Gowrisankaran, Sowjanya;Genead, Mohamed A.;Anastasakis, Anastasios;Alexander, Kenneth R.
通讯作者：
Alexander, Kenneth R.
影响因子：
4.4
作者：
North, Rachel V.;Jones, Adrian L.;Morgan, James E.
通讯作者：
Morgan, James E.
影响因子：
--
作者：
Medeiros, Felipe A.;Lisboa, Renato;Weinreb, Robert N.;Girkin, Christopher A.;Liebmann, Jeffrey M.;Zangwill, Linda M.
通讯作者：
Zangwill, Linda M.
DOI：
10.1007/s10633-018-9638-x
发表时间：
2018-06
期刊：
Documenta ophthalmologica. Advances in ophthalmology
影响因子：
--
作者：
Frishman L;Sustar M;Kremers J;McAnany JJ;Sarossy M;Tzekov R;Viswanathan S
通讯作者：
Viswanathan S