Sex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder.
Sex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder.
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DOI：
10.1016/j.jpsychires.2013.02.003
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发表时间：
2013-06
影响因子：
4.8
通讯作者：
Wang, Fei
中科院分区：
文献类型：
--
作者：
Kong, Lingtao;Chen, Kaiyuan;Womer, Fay;Jiang, Wenyan;Luo, Xingguang;Driesen, Naomi;Liu, Jie;Blumberg, Hilary;Tang, Yanqing;Xu, Ke;Wang, Fei
关键词：
在重度抑郁症（MDD）的流行病学和临床方面观察到性别差异。皮质边缘纹状体神经系统，包括前额皮质、杏仁核、海马体和纹状体，已经显示出两性二态的形态特征，并与MDD患者情绪和情绪的功能失调调节有关。在这项研究中，我们利用全脑，基于体素的方法来检查medication-naïve MDD参与者灰质（GM）形态异常区域分布的性别差异。参与者包括29名medication-naïve重度抑郁症患者（16名女性和13名男性）和33名健康对照组（17名女性和16名男性）。使用高分辨率结构磁共振成像扫描的基于体素的形态分析来检查皮质-边缘-纹状体神经系统的灰质形态。MDD组和HC组比较，诊断的主效应和性别诊断的交互效应对左侧前额叶腹侧皮层、右侧杏仁核、右侧海马和双侧尾状核GM形态学的影响有统计学意义（p<0.05，校正）。事后分析显示，与HC女性相比，MDD女性边缘区GM显著减少（p<0.05，校正）；与HC男性相比，MDD男性纹状体区域GM显著减少（p<0.05，校正）。观察到的皮质-边缘-纹状体神经系统异常的性别相关模式，如MDD女性中主要的前额叶-边缘异常与MDD男性中主要的前额叶-纹状体异常，表明神经回路的差异可能介导MDD临床表现的性别差异，以及性别分化治疗该疾病的潜在目标。
Sex differences are observed in both epidemiological and clinical aspects of major depressive disorder (MDD). The cortico-limbic-striatal neural system, including the prefrontal cortex, amygdala, hippocampus, and striatum, have shown sexually dimorphic morphological features and have been implicated in the dysfunctional regulation of mood and emotion in MDD. In this study, we utilized a whole-brain, voxel-based approach to examine sex differences in the regional distribution of gray matter (GM) morphological abnormalities in medication-naïve participants with MDD. Participants included 29 medication-naïve individuals with MDD (16 females and 13 males) and 33 healthy controls (HC) (17 females and 16 males). Gray matter morphology of the cortico-limbic-striatal neural system was examined using voxel-based morphometry analyses of high-resolution structural magnetic resonance imaging scans. The main effect of diagnosis and interaction effect of diagnosis by sex on GM morphology were statistically significant (p<0.05, corrected) in the left ventral prefrontal cortex, right amygdala, right hippocampus and bilateral caudate when comparing the MDD and HC groups. Posthoc analyses showed that females with MDD had significant GM decreases in limbic regions (p<0.05, corrected), compared to female HC; while males with MDD demonstrated significant GM reduction in striatal regions, (p<0.05, corrected), compared to HC males. The observed sex-related patterns of abnormalities within the cortico-limbic-strial neural system, such as predominant prefrontal-limbic abnormalities in MDD females vs. predominant prefrontal-striatal abnormalities in MDD males, suggest differences in neural circuitry that may mediate sex differences in the clinical presentation of MDD and potential targets for sex-differentiated treatment of the disorder.
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影响因子：
2.7
作者：
Davis, Matthew J.;Haley, Tammie;Duvoisin, Robert M.;Raber, Jacob
通讯作者：
Raber, Jacob
影响因子：
10.6
作者：
Blumberg, Hilary P.;Wang, Fei;Chepenik, Lara G.;Kalmar, Jessica H.;Edmiston, Elliot Kale;Duman, Ronald S.;Gelernter, Joel
通讯作者：
Gelernter, Joel
影响因子：
--
作者：
Edmiston, Erin E.;Wang, Fei;Mazure, Carolyn M.;Guiney, Joanne;Sinha, Rajita;Mayes, Linda C.;Blumberg, Hilary P.
通讯作者：
Blumberg, Hilary P.
影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
6.6
作者：
KESSLER, RC;MCGONAGLE, KA;NELSON, CB
通讯作者：
NELSON, CB