COVID-19 mRNA Vaccination in Lactation: Assessment of Adverse Events and Vaccine Related Antibodies in Mother-Infant Dyads.
COVID-19 mRNA Vaccination in Lactation: Assessment of Adverse Events and Vaccine Related Antibodies in Mother-Infant Dyads.
复制标题
DOI：
10.3389/fimmu.2021.777103
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Gaw SL
中科院分区：
文献类型：
--
作者：
Golan Y;Prahl M;Cassidy AG;Gay C;Wu AHB;Jigmeddagva U;Lin CY;Gonzalez VJ;Basilio E;Chidboy MA;Warrier L;Buarpung S;Li L;Murtha AP;Asiodu IV;Ahituv N;Flaherman VJ;Gaw SL
需要有关哺乳期母婴二分体的症状及其在哺乳期对COVID-19 mRNA疫苗接种的免疫应答的数据，以告知疫苗接种指南。从接受基于mRNA的COVID-19疫苗（mRNA-1273和BNT 162 b2）的50名哺乳期个体的前瞻性队列中，在第一次接种前、第二次接种前即刻和第二次接种后4-10周采集血液和乳汁样本。通过详细的问卷调查评估母亲和婴儿的症状。通过Pylon 3D自动免疫分析和ELISA测量血液和牛奶中的抗SARS-CoV-2抗体水平。此外，通过ELISA测量乳汁中疫苗相关的PEG化蛋白。从哺乳期（母亲第2次接种后4-15周）接种疫苗的母亲的婴儿亚组中采集血样。该队列中未报告重度母体或婴儿不良事件。在研究期间，两名母亲和两名婴儿在获得完全免疫应答之前被诊断出患有COVID-19。接种后，在乳汁中未发现显著水平的聚乙二醇化蛋白。接种疫苗后，母亲血浆中抗SARS-CoV-2 IgG和IgM水平显著升高，抗SARS-CoV-2受体结合域（抗RBD）伊加和IgG抗体显著转移到乳汁中。第二次剂量后的牛奶伊加水平与婴儿年龄呈负相关。母亲在哺乳期接种疫苗的婴儿血浆中未检测到抗SARS-CoV-2 IgG抗体。COVID-19 mRNA疫苗在哺乳期个体的血浆和乳汁中产生强大的免疫应答，未报告严重不良事件。
Data regarding symptoms in the lactating mother-infant dyad and their immune response to COVID-19 mRNA vaccination during lactation are needed to inform vaccination guidelines. From a prospective cohort of 50 lactating individuals who received mRNA-based vaccines for COVID-19 (mRNA-1273 and BNT162b2), blood and milk samples were collected prior to first vaccination dose, immediately prior to 2nd dose, and 4-10 weeks after 2nd dose. Symptoms in mother and infant were assessed by detailed questionnaires. Anti-SARS-CoV-2 antibody levels in blood and milk were measured by Pylon 3D automated immunoassay and ELISA. In addition, vaccine-related PEGylated proteins in milk were measured by ELISA. Blood samples were collected from a subset of infants whose mothers received the vaccine during lactation (4-15 weeks after mothers’ 2nd dose). No severe maternal or infant adverse events were reported in this cohort. Two mothers and two infants were diagnosed with COVID-19 during the study period before achieving full immune response. PEGylated proteins were not found at significant levels in milk after vaccination. After vaccination, levels of anti-SARS-CoV-2 IgG and IgM significantly increased in maternal plasma and there was significant transfer of anti-SARS-CoV-2-Receptor Binding Domain (anti-RBD) IgA and IgG antibodies to milk. Milk IgA levels after the 2nd dose were negatively associated with infant age. Anti-SARS-CoV-2 IgG antibodies were not detected in the plasma of infants whose mothers were vaccinated during lactation. COVID-19 mRNA vaccines generate robust immune responses in plasma and milk of lactating individuals without severe adverse events reported.
登录
查看更多内容
影响因子：
168.9
作者：
Amirthalingam, Gayatri;Andrews, Nick;Ramsay, Mary
通讯作者：
Ramsay, Mary
影响因子：
11.8
作者：
Dabrera, Gavin;Amirthalingam, Gayatri;Ramsay, Mary
通讯作者：
Ramsay, Mary
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
5.8
作者：
Fox A;Marino J;Amanat F;Krammer F;Hahn-Holbrook J;Zolla-Pazner S;Powell RL
通讯作者：
Powell RL
影响因子：
2.6
作者：
Baird, Jill K.;Jensen, Shawn M.;Baird, Jason R.
通讯作者：
Baird, Jason R.