Exploring the multiphysics of the brain during development, aging, and in neurological diseases

Exploring the multiphysics of the brain during development, aging, and in neurological diseases
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探索大脑在发育、衰老和神经系统疾病过程中的多物理现象

DOI:
10.1016/j.brain.2023.100068
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发表时间:
2023
期刊:
影响因子:
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通讯作者:
Weickenmeier, Johannes
Weickenmeier, Johannes
中科院分区:
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文献类型:
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作者:
Weickenmeier, Johannes

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人类的大脑仍然是一个无尽的奇迹之源,代表着一个侵入性的科学前沿。多物理学方法自然有助于将我们关于衰老和疾病的神经生物学的广泛知识与力学结合起来,以更好地捕捉大脑的多尺度行为。我们的团队使用实验方法,医学图像分析和组成建模来开发更好的疾病模型,其长期目标是改善诊断,治疗,并最终能够预防许多流行的年龄和疾病相关的大脑变化。在目前的角度来看,我们概述了正在进行的工作与神经发育,衰老和神经退行性疾病。
The human brain remains an endless source of wonder and represents an intruiging scientific frontier. Multiphysics approaches naturally lend themselves to combine our extensive knowledge about the neurobiology of aging and diseases with mechanics to better capture the multiscale behavior of the brain. Our group uses experimental methods, medical image analysis, and constitutive modeling to develop better disease models with the long-term goal to improve diagnosis, treatment, and ultimately enable prevention of many prevalent age- and disease-related brain changes. In the present perspective, we outline on-going work related to neurodevelopment, aging, and neurodegenerative disease.
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