Optoacoustic Monitoring of Physiologic Variables.
Optoacoustic Monitoring of Physiologic Variables.
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DOI：
10.3389/fphys.2017.01030
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发表时间：
2017
影响因子：
4
通讯作者：
Esenaliev RO
中科院分区：
文献类型：
--
作者：
Esenaliev RO
光声(光声)技术是一种新型的诊断平台，可用于生理参数的无创测量、功能成像和血流动力学监测。这项技术基于短光脉冲在组织中产生的光声(热弹性)波的产生和时间分辨检测。这提供了高光学对比度和超声空间分辨率的组织和单个血管的探测。由于光声波携带有关组织光学和热物理属性的信息，因此对光声波的检测和分析允许以高精度和特异度测量生理变量。我们建议使用光声技术来监测一些重要的生理变量，包括温度、热凝、冷冻、分子染料浓度、纳米颗粒、氧合和血红蛋白浓度。在这篇综述中，我们介绍了这些测量中对比度和高空间分辨率的起源，这些测量是由我们团队开发和建造的光声系统进行的。我们总结了在体外、在实验动物和在人类中获得的关于监测这些生理变量的数据。我们的数据表明，光声技术可用于脑外伤患者和新生儿的脑血氧监测，中心静脉氧合监测，总血红蛋白浓度监测，血肿检测和定征，温度监测，以及热疗中凝血和冷冻边界的监测。
Optoacoustic (photoacoustic) technique is a novel diagnostic platform that can be used for noninvasive measurements of physiologic variables, functional imaging, and hemodynamic monitoring. This technique is based on generation and time-resolved detection of optoacoustic (thermoelastic) waves generated in tissue by short optical pulses. This provides probing of tissues and individual blood vessels with high optical contrast and ultrasound spatial resolution. Because the optoacoustic waves carry information on tissue optical and thermophysical properties, detection, and analysis of the optoacoustic waves allow for measurements of physiologic variables with high accuracy and specificity. We proposed to use the optoacoustic technique for monitoring of a number of important physiologic variables including temperature, thermal coagulation, freezing, concentration of molecular dyes, nanoparticles, oxygenation, and hemoglobin concentration. In this review we present origin of contrast and high spatial resolution in these measurements performed with optoacoustic systems developed and built by our group. We summarize data obtained in vitro, in experimental animals, and in humans on monitoring of these physiologic variables. Our data indicate that the optoacoustic technology may be used for monitoring of cerebral blood oxygenation in patients with traumatic brain injury and in neonatal patients, central venous oxygenation monitoring, total hemoglobin concentration monitoring, hematoma detection and characterization, monitoring of temperature, and coagulation and freezing boundaries during thermotherapy.
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影响因子：
3.8
作者：
Daoudi, K.;van den Berg, P. J.;Steenbergen, W.
通讯作者：
Steenbergen, W.
DOI：
10.1109/2944.796320
发表时间：
1999-07-01
影响因子：
4.9
作者：
Esenaliev, RO;Karabutov, AA;Oraevsky, AA
通讯作者：
Oraevsky, AA
影响因子：
3.5
作者：
Ellwood, Robert;Zhang, Edward;Cox, Ben
通讯作者：
Cox, Ben
影响因子：
3.4
作者：
Larin, KV;Larina, IV;Esenaliev, RO
通讯作者：
Esenaliev, RO
影响因子：
1.9
作者：
Esenaliev, RO;Petrov, YY;Prough, DS
通讯作者：
Prough, DS