Preparation and Properties of Nanoparticles of Calcium Phosphates With Various Ca/P Ratios.
Preparation and Properties of Nanoparticles of Calcium Phosphates With Various Ca/P Ratios.
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DOI：
10.6028/jres.115.018
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发表时间：
2010-07
影响因子：
1.5
通讯作者：
Bonevich JE
中科院分区：
文献类型：
--
作者：
Sun L;Chow LC;Frukhtbeyn SA;Bonevich JE
本研究旨在利用喷雾干燥技术制备钙磷比为1.0~1.67的纳米磷酸钙(NCAP)，并对其性能进行研究。微观结构分析表明，钙磷比为1.67~1.33的NCAP为纳米级无定形磷酸钙(ACP)，含有不同量的酸性磷酸盐和碳酸盐。钙磷比为1的NCAP中只含有纳米级低结晶磷酸氢钙(DCP)。NCAP的BET测量显示，比表面积为(12±2至50±1)m2/g，对应于估计的等效球径(38至172)nm。然而，扫描电子显微镜(SEM)显示，由于较小的一次纳米颗粒的团聚，动态光散射测量显示出(380±49)nm到(768±111)nm的大得多的颗粒。热力学溶解度测定表明，钙磷比为1.33~1.67的NCAP具有相似的溶解行为。该材料在pH>4.7时比结晶型羟基磷灰石(HA)更易溶解，在pH>5.5时比磷酸三钙(β-β)、磷酸八钙(OCP)和磷酸三钙(DCP)更易溶解。在pH值为7左右时，它们的溶解度接近α-磷酸三钙(α-TcP)。这些NCAP不容易用其他现有的纳米颗粒制备方法制备，具有潜在的生物医学应用。
This study aimed at preparing and studying the properties of nanoparticles of calcium phosphate (nCaP) with Ca/P ratios ranging from 1.0 to 1.67 using a spray-drying technique. Micro-structural analyses suggested that the nCaPs with Ca/P ratios of 1.67 to 1.33 were nano-sized amorphous calcium phosphate (ACP) containing varying amounts of acid phosphate and carbonate. The nCaP with Ca/P ratio of 1 contained only nano-sized low crystalline dicalcium phosphate (DCP). BET measurements of the nCaPs showed specific surface areas of (12 ± 2 to 50 ± 1) m2/g, corresponding to estimated equivalent spherical diameters of (38 to 172) nm. However, dynamic light scattering measurements revealed much larger particles of (380 ± 49 to 768 ± 111) nm, owing to agglomeration of the smaller primary nano particles as revealed by Scanning Electron Microscopy (SEM). Thermodynamic solubility measurements showed that the nCaPs with Ca/P ratio of 1.33 – 1.67 all have similar solubility behavior. The materials were more soluble than the crystalline hydroxyapatite (HA) at pH greater than about 4.7, and more soluble than β-tricalcium phosphate (β-TCP), octacalcium phosphate (OCP) and DCP at pH above 5.5. Their solubility approached that of α-tricalcium phosphate (α-TCP) at about pH 7. These nCaPs, which cannot be readily prepared by other currently available methods for nanoparticle preparation, have potential biomedical applications.
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影响因子：
3.9
作者：
Bertoni, E;Bigi, A;Roveri, N
通讯作者：
Roveri, N
影响因子：
2.8
作者：
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通讯作者：
Glimcher, MJ
DOI：
10.1111/j.1151-2916.1998.tb02499.x
发表时间：
1998-06-01
影响因子：
3.9
作者：
Layrolle, P;Ito, A;Tateishi, T
通讯作者：
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影响因子：
4.2
作者：
VOGEL, GL;CHOW, LC;BROWN, WE
通讯作者：
BROWN, WE
影响因子：
14
作者：
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通讯作者：
Eldelman, N