Diamond thin films: giving biomedical applications a new shine.
Diamond thin films: giving biomedical applications a new shine.
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DOI：
10.1098/rsif.2017.0382
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
May PW
中科院分区：
文献类型：
--
作者：
Nistor PA;May PW
过去二十年来，化学气相沉积技术取得的进展使生产廉价、高质量的金刚石涂层成为科学和商业现实。金刚石的两个特性使其成为生物医学应用中非常理想的候选材料：首先，它是生物惰性的，这意味着当金刚石植入体内时，免疫反应最小;其次，它的导电性可以以受控的方式改变，从绝缘到接近金属。在体外，金刚石可以用作一种基质，在其上可以培养一系列生物细胞。在体内，金刚石薄膜已被提议作为植入物和假体的涂层。在这里，我们回顾了大量的数据，关于使用金刚石基板在体外细胞培养。我们还详细介绍了最近的工作，探索金刚石涂层植入物的主要目标是骨骼和神经组织。我们的结论是，金刚石作为21世纪世纪的主要新生物材料之一，可以塑造医疗方式，特别是当需要侵入性手术时。
Progress made in the last two decades in chemical vapour deposition technology has enabled the production of inexpensive, high-quality coatings made from diamond to become a scientific and commercial reality. Two properties of diamond make it a highly desirable candidate material for biomedical applications: first, it is bioinert, meaning that there is minimal immune response when diamond is implanted into the body, and second, its electrical conductivity can be altered in a controlled manner, from insulating to near-metallic. In vitro, diamond can be used as a substrate upon which a range of biological cells can be cultured. In vivo, diamond thin films have been proposed as coatings for implants and prostheses. Here, we review a large body of data regarding the use of diamond substrates for in vitro cell culture. We also detail more recent work exploring diamond-coated implants with the main targets being bone and neural tissue. We conclude that diamond emerges as one of the major new biomaterials of the twenty-first century that could shape the way medical treatment will be performed, especially when invasive procedures are required.
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4.3
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