Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding.
Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding.
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DOI：
10.1038/s41467-021-22430-7
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发表时间：
2021-04-09
影响因子：
16.6
通讯作者：
Malenka RC
中科院分区：
文献类型：
--
作者：
Christoffel DJ;Walsh JJ;Heifets BD;Hoerbelt P;Neuner S;Sun G;Ravikumar VK;Wu H;Halpern CH;Malenka RC
享乐喂养是由来自食用可口食物的“快乐”驱动的，并且在没有代谢需要的情况下发生。它在导致肥胖的过度喂养中起着关键作用。与其他病理性动机行为相比，人们对过度享乐进食的神经回路机制知之甚少。在这里，我们表明，调制的前额叶皮层（PFC）和室旁丘脑（aPVT）兴奋性输入到丘脑核（NAc），一个关键节点的奖励电路，具有相反的影响高脂肪摄入量的小鼠。长时间的高脂肪摄入导致突触强度的输入和细胞类型特异性变化。通过可塑性方案，以输入特异性光遗传学或非特异性电方式修改突触强度，导致高脂肪摄入的持续变化。这些结果表明，输入特定的NAC电路的适应性发生反复暴露于一个强大的自然奖励，并建议神经调节干预可能是治疗上有用的个人病理性享乐喂养。享乐喂养发生在没有代谢需要的情况下，在肥胖的过度喂养中起着关键作用。作者表明，来自前额皮质的NAc输入的光遗传学操纵与来自丘脑室旁前核的输入对高脂肪摄入具有相反的影响。
Hedonic feeding is driven by the “pleasure” derived from consuming palatable food and occurs in the absence of metabolic need. It plays a critical role in the excessive feeding that underlies obesity. Compared to other pathological motivated behaviors, little is known about the neural circuit mechanisms mediating excessive hedonic feeding. Here, we show that modulation of prefrontal cortex (PFC) and anterior paraventricular thalamus (aPVT) excitatory inputs to the nucleus accumbens (NAc), a key node of reward circuitry, has opposing effects on high fat intake in mice. Prolonged high fat intake leads to input- and cell type-specific changes in synaptic strength. Modifying synaptic strength via plasticity protocols, either in an input-specific optogenetic or non-specific electrical manner, causes sustained changes in high fat intake. These results demonstrate that input-specific NAc circuit adaptations occur with repeated exposure to a potent natural reward and suggest that neuromodulatory interventions may be therapeutically useful for individuals with pathologic hedonic feeding. Hedonic feeding occurs in the absence of metabolic need and plays a critical role in the excessive feeding that underlies obesity. The authors show that optogenetic manipulation of NAc inputs from the prefrontal cortex versus inputs from the anterior paraventricular nucleus of the thalamus has opposite effects on high fat intake.
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影响因子：
8.8
作者：
Lafferty, Christopher K.;Yang, Angela K.;Britt, Jonathan P.
通讯作者：
Britt, Jonathan P.
DOI：
10.1523/jneurosci.0197-10.2010
发表时间：
2010-03-31
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Krause M;German PW;Taha SA;Fields HL
通讯作者：
Fields HL
影响因子：
10.6
作者：
Brown RM;Kupchik YM;Spencer S;Garcia-Keller C;Spanswick DC;Lawrence AJ;Simonds SE;Schwartz DJ;Jordan KA;Jhou TC;Kalivas PW
通讯作者：
Kalivas PW
DOI：
10.1523/jneurosci.3237-12.2013
发表时间：
2013-04-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Halpern CH;Tekriwal A;Santollo J;Keating JG;Wolf JA;Daniels D;Bale TL
通讯作者：
Bale TL
影响因子：
13.8
作者：
Hearing M;Graziane N;Dong Y;Thomas MJ
通讯作者：
Thomas MJ