The effect of temperature on persistence of SARS-CoV-2 on common surfaces.
The effect of temperature on persistence of SARS-CoV-2 on common surfaces.
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DOI：
10.1186/s12985-020-01418-7
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发表时间：
2020-10-07
期刊：
影响因子：
4.8
通讯作者：
Drew TW
中科院分区：
文献类型：
--
作者：
Riddell S;Goldie S;Hill A;Eagles D;Drew TW
COVID-19 在全球范围内的传播速度令人震惊。虽然污染物传播的作用尚未完全了解，但需要有关 SARS-CoV-2 环境稳定性的精确数据来确定污染物从受污染表面传播的风险。本研究测量了悬浮在标准 ASTM E2197 基质中的传染性 SARS-CoV-2 在几种常见表面类型上的存活率。所有实验均在黑暗中进行，以消除紫外线的任何影响。接种表面在 20°C、30°C 和 40°C 下孵育，并在不同时间点取样。测定不同温度下 SARS-CoV-2 的存活率，并计算 D 值、Z 值和半衰期。我们在 20 °C 时获得了 1.7 至 2.7 天的半衰期，当温度升高至 40 °C 时半衰期缩短至几个小时。由于初始病毒载量大致相当于感染性患者排出的最高滴度，在 20°C 的条件下，可以从玻璃、不锈钢以及纸币和聚合物钞票等常见表面分离出活病毒长达 28 天。相反，传染性病毒在 40°C 的某些表面上存活时间不到 24 小时。这些发现表明，SARS-CoV-2 保持传染性的时间比普遍认为的时间要长得多。这些结果可用于改进风险缓解程序，以防止 COVID-19 的传播。
The rate at which COVID-19 has spread throughout the globe has been alarming. While the role of fomite transmission is not yet fully understood, precise data on the environmental stability of SARS-CoV-2 is required to determine the risks of fomite transmission from contaminated surfaces. This study measured the survival rates of infectious SARS-CoV-2, suspended in a standard ASTM E2197 matrix, on several common surface types. All experiments were carried out in the dark, to negate any effects of UV light. Inoculated surfaces were incubated at 20 °C, 30 °C and 40 °C and sampled at various time points. Survival rates of SARS-CoV-2 were determined at different temperatures and D-values, Z-values and half-life were calculated. We obtained half lives of between 1.7 and 2.7 days at 20 °C, reducing to a few hours when temperature was elevated to 40 °C. With initial viral loads broadly equivalent to the highest titres excreted by infectious patients, viable virus was isolated for up to 28 days at 20 °C from common surfaces such as glass, stainless steel and both paper and polymer banknotes. Conversely, infectious virus survived less than 24 h at 40 °C on some surfaces. These findings demonstrate SARS-CoV-2 can remain infectious for significantly longer time periods than generally considered possible. These results could be used to inform improved risk mitigation procedures to prevent the fomite spread of COVID-19.
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影响因子：
3.7
作者：
Dublineau, Amelie;Batejat, Christophe;Manuguerra, Jean-Claude
通讯作者：
Manuguerra, Jean-Claude
影响因子：
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作者：
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DOI：
10.1007/s10096-020-03913-9
发表时间：
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通讯作者：
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影响因子：
11.8
作者：
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