Hierarchical genetic organization of human cortical surface area.
Hierarchical genetic organization of human cortical surface area.
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DOI：
10.1126/science.1215330
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发表时间：
2012-03-30
期刊：
影响因子：
--
通讯作者：
Dale AM
中科院分区：
文献类型：
--
作者：
Chen CH;Gutierrez ED;Thompson W;Panizzon MS;Jernigan TL;Eyler LT;Fennema-Notestine C;Jak AJ;Neale MC;Franz CE;Lyons MJ;Grant MD;Fischl B;Seidman LJ;Tsuang MT;Kremen WS;Dale AM
大脑皮层的表面积是一个高度遗传的特征，但很少有人知道遗传对人类区域皮层分化的影响。使用数据驱动的模糊聚类技术与来自406对双胞胎的磁共振成像数据，我们将皮质表面区域划分为遗传细分，仅基于遗传信息数据创建人脑图谱。边界的遗传部门在很大程度上对应有意义的结构和功能区域，然而，该司代表以前未描述的表型不同于传统的（非遗传为基础的）包裹系统。皮质区的遗传组织是分层的，模块化的，主要是两侧对称的半球。我们还发现，结果是一致的，与人类特定的区域是以前描述的，遗传为基础的叶区域化模式的细分。
Surface area of the cerebral cortex is a highly heritable trait, yet little is known about genetic influences on regional cortical differentiation in humans. Using a data-driven, fuzzy clustering technique with magnetic resonance imaging data from 406 twins, we parceled cortical surface area into genetic subdivisions, creating a human brain atlas based solely on genetically informative data. Boundaries of the genetic divisions corresponded largely to meaningful structural and functional regions; however, the divisions represented previously undescribed phenotypes different from conventional (non–genetically based) parcellation systems. The genetic organization of cortical area was hierarchical, modular, and predominantly bilaterally symmetric across hemispheres. We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns.
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影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
64.8
作者：
FRASER, S;KEYNES, R;LUMSDEN, A
通讯作者：
LUMSDEN, A
影响因子：
56.9
作者：
Sun, T;Patoine, C;Walsh, CA
通讯作者：
Walsh, CA
影响因子：
16.2
作者：
Johnson, Matthew B.;Kawasawa, Yuka Imamura;Mason, Christopher E.;Krsnik, Zeljka;Coppola, Giovanni;Bogdanovic, Darko;Geschwind, Daniel H.;Mane, Shrikant M.;State, Matthew W.;Sestan, Nenad
通讯作者：
Sestan, Nenad
DOI：
10.1073/pnas.0901866106
发表时间：
2009-09-08
影响因子：
11.1
作者：
Joyner, Alexander H.;Roddey, J. Cooper;Dale, Anders M.
通讯作者：
Dale, Anders M.