Lactobacillus johnsonii N6.2 and Blueberry Phytophenols Affect Lipidome and Gut Microbiota Composition of Rats Under High-Fat Diet.
Lactobacillus johnsonii N6.2 and Blueberry Phytophenols Affect Lipidome and Gut Microbiota Composition of Rats Under High-Fat Diet.
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DOI：
10.3389/fnut.2021.757256
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发表时间：
2021
影响因子：
5
通讯作者：
Gonzalez CF
中科院分区：
文献类型：
--
作者：
Teixeira LD;Torrez Lamberti MF;DeBose-Scarlett E;Bahadiroglu E;Garrett TJ;Gardner CL;Meyer JL;Lorca GL;Gonzalez CF
肥胖被认为是许多疾病发展的主要因素，包括癌症、糖尿病和心血管疾病。富含植物化学物质的食物，与健康的胃肠道微生物区系有关，已被证明可以减少肥胖和相关的共病。在本文中，我们描述了益生菌约翰乳杆菌N6.2和蓝莓提取物(BB)在高脂肪(HF)或低热量(LC)饮食下对大鼠肠道微生物区系和血脂谱的影响。在HF饲料中，所有动物的血清中长链脂肪酸(LCFA)含量均升高，而在添加BB提取物的HF饲料中，动物脂肪组织中LCFA含量降低。所有饲喂HF饲料的动物也显示出较低的SREBP1和SCAP蛋白水平。在BB存在的情况下，约翰逊乳杆菌的肠道微生物区系多样性、β多样性发生了显著变化。在HF饲料中添加约翰逊乳杆菌和BB的动物回肠α多样性显著降低，而在LC饲料中添加约翰逊乳杆菌和BB的动物回肠α多样性显著增加。总之，添加强生乳杆菌和BB后，肠道微生物区系多样性和脂肪代谢发生了显著变化。磷脂池是直接受干预影响的脂体成分。回肠和结肠的微生物区系显示出明显的差异，这取决于所检查的饮食和治疗方法。
Obesity is considered a primary contributing factor in the development of many diseases, including cancer, diabetes, and cardiovascular illnesses. Phytochemical-rich foods, associated to healthy gastrointestinal microbiota, have been shown to reduce obesity and associated comorbidities. In the present article, we describe the effects of the probiotic Lactobacillus johnsonii N6.2 and blueberry extracts (BB) on the gut microbiota and lipid profile of rats under a high-fat (HF) or low-calorie (LC) diet. L. johnsonii was found to increase the levels of long chain fatty acids (LCFA) in the serum of all animals under HF diet, while reduced LCFA concentrations were observed in the adipose tissue of animals under HF diet supplemented with BB extracts. All animals under HF diet also showed lower protein levels of SREBP1 and SCAP when treated with L. johnsonii. The gut microbiota diversity, β-diversity was significantly changed by L. johnsonii in the presence of BB. A significant reduction in α-diversity was observed in the ileum of animals under HF diet supplemented with L. johnsonii and BB, while increased α-diversity was observed in the ilium of animals under LC diet supplemented with L. johnsonii or BB. In summary, L. johnsonii and BB supplementation induced significant changes in gut microbiota diversity and lipid metabolism. The phospholipids pool was the lipidome component directly affected by the interventions. The ileum and colon microbiota showed clear differences depending on the diet and the treatments examined.
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DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
16.2
作者：
Lehmann R;Franken H;Dammeier S;Rosenbaum L;Kantartzis K;Peter A;Zell A;Adam P;Li J;Xu G;Königsrainer A;Machann J;Schick F;Hrabé de Angelis M;Schwab M;Staiger H;Schleicher E;Gastaldelli A;Fritsche A;Häring HU;Stefan N
通讯作者：
Stefan N
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
5.6
作者：
De Boer, Anna A.;Monk, Jennifer M.;Robinson, Lindsay E.
通讯作者：
Robinson, Lindsay E.
影响因子：
4.3
作者：
Garrett, Timothy J.;Menger, Robert F.;Yost, Richard A.
通讯作者：
Yost, Richard A.