A facile synthesis of deaza-analogues of the bisindole marine alkaloid topsentin.
A facile synthesis of deaza-analogues of the bisindole marine alkaloid topsentin.
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Bisindole海洋生物碱topsentin的Deaza-Analogues的便捷合成。
DOI：
10.3390/molecules18032518
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发表时间：
2013-02-26
期刊：
影响因子：
--
通讯作者：
Favi G
中科院分区：
文献类型：
--
作者：
Carbone A;Spanò V;Parrino B;Ciancimino C;Attanasi OA;Favi G
A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5-(1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)carbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98%) by one-pot reactions between β-dicarbonyl compounds 12a–e and 1,2-diaza-1,3-diene (DD) 13. Derivatives 10a,c–e, deazaanalogues of the bis-indole alkaloid topsentin, screened by the National Cancer Institute (Bethesda, MD, USA) in the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity, with the exception of compound 9e, which showed moderate activity against the HOP-92 cell line of the non small cell lung cancer sub-panel and the SNB-75 cell line of the CNS sub-panel.
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DOI：
10.1093/jnci/83.11.757
发表时间：
1991-06-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
MONKS, A;SCUDIERO, D;BOYD, M
通讯作者：
BOYD, M
影响因子：
6.1
作者：
Gul W;Hamann MT
通讯作者：
Hamann MT
影响因子：
3.5
作者：
Jiang, B;Gu, XH
通讯作者：
Gu, XH
影响因子：
5.1
作者：
Bao, BQ;Sun, QS;Jung, JH
通讯作者：
Jung, JH
影响因子：
5.1
作者：
Casapullo, A;Bifulco, G;Riccio, R
通讯作者：
Riccio, R