Advanced parental age at birth is associated with poorer social functioning in adolescent males: shedding light on a core symptom of schizophrenia and autism.
Advanced parental age at birth is associated with poorer social functioning in adolescent males: shedding light on a core symptom of schizophrenia and autism.
复制标题
父母出生时的高龄与青春期男性社会功能较差有关：揭示了精神分裂症和自闭症的核心症状。
DOI：
10.1093/schbul/sbn109
复制
发表时间：
2008
影响因子：
6.6
通讯作者：
Davidson,Michael
中科院分区：
文献类型：
--
作者：
Weiser,Mark;Reichenberg,Abraham;Werbeloff,Nomi;Kleinhaus,Karine;Lubin,Gad;Shmushkevitch,Moti;Caspi,Asaf;Malaspina,Dolores;Davidson,Michael
背景：有证据表明出生时父母年龄较大与精神分裂症和自闭症风险增加有关。精神分裂症和自闭症患者及其一级亲属的社会功能受损;因此，社会功能受损可能是疾病的中间表型。这项研究验证了这样一个假设，即在一般人群中，父亲出生时的年龄越大，社会功能越差。为了验证这一假设，我们研究了父母的出生年龄和他们的青少年男性后代的社会功能之间的关联在人口为基础的study.Methods：主题是403 - 486，16- 17岁的以色列出生的男性青少年由以色列草案委员会评估。父母的年龄对社会功能的影响进行了评估，在控制认知功能的分析，另一个父母的年龄，父母的社会经济地位，出生顺序，和一年的草案委员会assessment.Results：与子女的父母年龄在25-29岁，社会功能不良的患病率增加，在子女的父亲小于20岁（比值比[OR] = 1.27，95%置信区间[CI] = 1.08-1.49）和子女的父亲45岁（OR = 1.52，95%CI = 1.43-1.61）。男性青少年儿童的母亲年龄在40岁及以上的1.15倍（95%CI = 1.07-1.24）更有可能有不良的社会functions.Conclusions：这些适度的关联父母年龄和社会功能差的一般人群平行的父母年龄和精神分裂症和自闭症的风险之间的关联，并建议，先进的父母年龄和精神分裂症和自闭症之间的风险途径可能，至少部分，包括轻度有害影响社会功能。
Background:Evidence indicates an association between older parents at birth and increased risk for schizophrenia and autism. Patients with schizophrenia and autism and their first-degree relatives have impaired social functioning; hence, impaired social functioning is probably an intermediate phenotype of the illness. This study tested the hypothesis that advanced father's age at birth would be associated with poorer social functioning in the general population. To test this hypothesis, we examined the association between parental age at birth and the social functioning of their adolescent male offspring in a population-based study.Methods:Subjects were 403 486, 16- to 17-year-old Israeli-born male adolescents assessed by the Israeli Draft Board. The effect of parental age on social functioning was assessed in analyses controlling for cognitive functioning, the other parent's age, parental socioeconomic status, birth order, and year of draft board assessment.Results:Compared with offspring of parents aged 25–29 years, the prevalence of poor social functioning was increased both in offspring of fathers younger than 20 years (odds ratio [OR] = 1.27, 95% confidence interval [CI] = 1.08–1.49) and in offspring of fathers 45 years old (OR = 1.52, 95% CI = 1.43–1.61). Male adolescent children of mothers aged 40 years and above were 1.15 (95% CI = 1.07–1.24) times more likely to have poor social functioning.Conclusions:These modest associations between parental age and poor social functioning in the general population parallel the associations between parental age and risk for schizophrenia and autism and suggest that the risk pathways between advanced parental age and schizophrenia and autism might, at least partially, include mildly deleterious effects on social functioning.
登录
查看更多内容
DOI：
10.1097/00006254-200302000-00005
发表时间：
2002-09
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Alan S. Brown;C. Schaefer;R. Wyatt;M. Begg;R. Goetz;M. Bresnahan;J. Harkavy-Friedman;J. Gorman;D. Malaspina;E. Susser
通讯作者：
Alan S. Brown;C. Schaefer;R. Wyatt;M. Begg;R. Goetz;M. Bresnahan;J. Harkavy-Friedman;J. Gorman;D. Malaspina;E. Susser
父亲年龄低于或高于 35 岁与后代患精神分裂症的不同风险相关
影响因子：
7.8
作者：
M. Wohl;P. Gorwood
通讯作者：
P. Gorwood
表面健康的男性青少年精神分裂症的行为和智力标志。
DOI：
10.1176/ajp.156.9.1328
发表时间：
1999
期刊：
The American journal of psychiatry
影响因子：
--
作者：
M. Davidson;A. Reichenberg;J. Rabinowitz;M. Weiser;Z. Kaplan;Mordehai Mark
通讯作者：
Mordehai Mark
影响因子：
3.5
作者：
Cardwell, CR;Carson, DJ;Patterson, CC
通讯作者：
Patterson, CC
DOI：
--
发表时间：
1998
期刊：
--
影响因子：
--
作者：
R. Wells;S. Warren;M. Sarmiento
通讯作者：
R. Wells;S. Warren;M. Sarmiento