Lactoferrin in cerebrospinal fluid and saliva is not a diagnostic biomarker for Alzheimer's disease in a mixed memory clinic population.
Lactoferrin in cerebrospinal fluid and saliva is not a diagnostic biomarker for Alzheimer's disease in a mixed memory clinic population.
复制标题
DOI：
10.1016/j.ebiom.2021.103361
复制
发表时间：
2021-05
期刊：
影响因子：
11.1
通讯作者：
Simonsen AH
中科院分区：
文献类型：
--
作者：
Gleerup HS;Jensen CS;Høgh P;Hasselbalch SG;Simonsen AH
阿尔茨海默病（AD）和其他神经退行性疾病的病理变化在其临床表现之前开始数十年。然而，神经退行性痴呆的临床诊断并不简单。乳铁蛋白是一种铁结合的抗微生物糖蛋白，具有多种功能，包括作为重要的免疫调节剂和具有杀菌作用。先前的两项研究表明，唾液乳铁蛋白可以区分神经退行性痴呆。共222个脑脊液（CSF）和唾液样本的连续，混合记忆诊所人口进行了分析乳铁蛋白。此外，还讨论了CSF和唾液中乳铁蛋白与CSF中tau、磷酸化tau（p-tau）和淀粉样蛋白1-42（Aβ42）浓度之间的相关性。首次在神经退行性痴呆患者队列中评估CSF乳铁蛋白。在诊断组之间没有发现CSF或唾液乳铁蛋白水平的显著差异。此外，未发现乳铁蛋白水平分别与tau、p-tau和Aβ42之间存在显著关系。在这项研究中，CSF和唾液乳铁蛋白都不能区分神经退行性痴呆。
The pathological changes in Alzheimer's Disease (AD) and other neurodegenerative disorders begin decades prior to their clinical expression. However, the clinical diagnosis of neurodegenerative dementias is not straightforward. Lactoferrin is an iron-binding, antimicrobial glycoprotein with a plethora of functions, including acting as an important immune modulator and by having a bacteriocidic effect. Two previous studies indicated that salivary lactoferrin could differentiate between neurodegenerative dementias. A total of 222 cerebrospinal fluid (CSF) and saliva samples from a consecutive, mixed memory clinic population were analysed for lactoferrin. In addition, the association between lactoferrin in CSF and saliva and the concentration of tau, phosphorylated tau (p-tau) and amyloid 1–42 (Aβ42) in CSF were addressed. CSF lactoferrin was assessed for the first time in a cohort of patients with neurodegenerative dementias. No significant differences were found in the levels of CSF or saliva lactoferrin between the diagnostic groups. In addition, no significant relationships were found between lactoferrin levels and tau, p-tau and Aβ42, respectively. Neither CSF nor saliva lactoferrin could differentiate between neurodegenerative dementias in this study.
登录
查看更多内容
影响因子：
--
作者：
Malamud D
通讯作者：
Malamud D
影响因子：
4.3
作者：
Adam, DJ;Milne, AA;Bradbury, AW
通讯作者：
Bradbury, AW
影响因子：
5.9
作者：
Emmons, Wesley
通讯作者：
Emmons, Wesley
影响因子：
4.6
作者：
Jasim H;Carlsson A;Hedenberg-Magnusson B;Ghafouri B;Ernberg M
通讯作者：
Ernberg M
DOI：
10.1016/j.dadm.2017.04.002
发表时间：
2017
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Carro E;Bartolomé F;Bermejo-Pareja F;Villarejo-Galende A;Molina JA;Ortiz P;Calero M;Rabano A;Cantero JL;Orive G
通讯作者：
Orive G