Neuroticism modulates the effects of intranasal vasopressin treatment on the neural response to positive and negative social interactions.
Neuroticism modulates the effects of intranasal vasopressin treatment on the neural response to positive and negative social interactions.
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DOI：
10.1016/j.neuropsychologia.2015.05.004
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发表时间：
2015-07
期刊：
影响因子：
2.6
通讯作者：
Rilling, James K.
中科院分区：
文献类型：
--
作者：
Feng, Chunliang;DeMarco, Ashley C.;Haroon, Ebrahim;Rilling, James K.
神经质是一种基本的人格特征，与感觉负面情绪的倾向有关。在这里，我们问神经质如何影响对积极和消极社会互动的神经反应，以及神经质如何调节鼻腔内催产素(OT)和加压素(AVP)对社会互动神经反应的影响。在一项双盲、安慰剂对照研究中，153名男性参与者被随机分成三组，分别接受24IU鼻腔注射OT、20IU AVP或安慰剂。之后，他们在玩重复的囚徒困境游戏时接受了功能磁共振成像。在另一天，受试者完成了NEO人格问卷，以测量神经质。神经质与前扣带回/额叶内侧皮质对负性社会交往的神经反应和对岛上正向社会交往的神经反应呈正相关，表明神经质对负性社会交往和积极社会交往的神经心理加工均有调节作用。神经质并不影响鼻腔催产素治疗对积极或消极社会互动的神经反应的影响。另一方面，AVP治疗显著地与神经质相互作用，调节对积极和消极社会互动的大胆反应。具体地说，在神经质得分较高而不是较低的参与者中，AVP在更大程度上增加了前扣带回皮质/内侧前额叶皮质和外侧颞叶对负面社交互动的反应。在神经质得分较高而不是较低的参与者中，AVP还在更大程度上增加了脑岛对积极社交互动的反应。这些结果表明，与神经质低的个体相比，AVP可能在更大程度上增加了对消极社会互动的情绪调节，并在更大程度上突出了积极社会互动。目前的发现敦促人们警惕临床上统一使用非肽类药物，并表明它们的疗效可能会因个性而异。
Neuroticism is a fundamental personality trait associated with proneness to feel negative affect. Here we ask how Neuroticism influences the neural response to positive and negative social interactions and how Neuroticism modulates the effect of intranasal oxytocin (OT) and vasopressin (AVP) on the neural response to social interactions. In a double-blind, placebo-controlled study, 153 male participants were randomized to receive 24 IU intranasal OT, 20 IU AVP or placebo. Afterwards, they were imaged with fMRI while playing an iterated Prisoner’s Dilemma Game. On a different day, subjects completed the NEO personality inventory to measure Neuroticism. Neuroticism was positively correlated with the neural response to negative social interactions in the anterior cingulate cortex/medial prefrontal cortex and with the neural response to positive social interactions in the insula, indicating that Neuroticism modulates neuropsychological processing of both negative and positive social interactions. Neuroticism did not modulate the effect of intranasal OT treatment on the neural response to either positive or negative social interactions. On the other hand, AVP treatment significantly interacted with Neuroticism to modulate the BOLD response to both positive and negative social interactions. Specifically, AVP increased anterior cingulate cortex/medial prefrontal cortex and lateral temporal lobe responses to negative social interactions to a greater extent in participants scoring high rather than low on Neuroticism. AVP also increased the insula response to positive social interactions to a greater extent in participants scoring high rather than low on Neuroticism. These results imply that AVP may increase emotion regulation in response to negative social interactions and the salience of positive social interactions to a greater extent in individuals high compared to low in Neuroticism. The current findings urge caution against uniform clinical application of nonapeptides and suggest that their efficacy may vary as a function of personality.
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