Cytoarchitecture of the lateral ganglionic eminence and rostral extension of the lateral ventricle in the human fetal brain.
Cytoarchitecture of the lateral ganglionic eminence and rostral extension of the lateral ventricle in the human fetal brain.
复制标题
DOI：
10.1002/cne.22566
复制
发表时间：
2011-04-15
影响因子：
2.5
通讯作者：
Quinones-Hinojosa, Alfredo
中科院分区：
文献类型：
--
作者：
Guerrero-Cazares, Hugo;Gonzalez-Perez, Oscar;Soriano-Navarro, Mario;Zamora-Berridi, Grettel;Manuel Garcia-Verdugo, Jose;Quinones-Hinojosa, Alfredo
胎儿前脑室下区(SVZ)的发育包括放射状胶质细胞向神经干细胞的转化，以及神经母细胞从SVZ向脑内不同区域的迁移。在成年啮齿动物中，这种从SVZ前部的迁移仅限于嗅球，沿着由迁移性神经母细胞链形成的嘴迁移流(RMS)。与啮齿动物类似，RMS已被认为存在于成年人的大脑中，在那里SVZ仍然是一个活跃的增殖区。然而，人类胎儿RMS还没有被描述，成人中是否存在迁移性神经母细胞仍然存在争议。在这里，我们描述了发育中期(怀孕23-24周)人SVZ在外侧神经节隆起的细胞构筑。该区域的细胞结构沿脑室壁呈异质性，GFAP阳性细胞排列在脑室。这些细胞共表达放射状胶质细胞的标志，如胶质纤维酸性蛋白δ、巢蛋白和波形蛋白。我们还显示在前角SVZ中存在大量的迁移性神经母细胞，形成了以细胞群命名的结构。有趣的是，侧脑室腹侧延伸提示可能存在RMS。然而，在嗅球中没有观察到神经母细胞群或链状结构。缺乏这些靠近嗅球的结构可能表明人类大脑中嗅球外的迁移神经母细胞的目的地。
The fetal development of the anterior subventricular zone (SVZ) involves the transformation of radial glia into neural stem cells, in addition to the migration of neuroblasts from the SVZ towards different regions in the brain. In adult rodents this migration from the anterior SVZ is restricted to the olfactory bulb following a rostral migratory stream (RMS) formed by chains of migratory neuroblasts. Similar to rodents, an RMS has been suggested in the adult human brain, where the SVZ remains as an active proliferative region. Nevertheless, a human fetal RMS has not been described and the presence of migratory neuroblasts in the adult remains controversial. Here we describe the cytoarchitecture of the human SVZ at the lateral ganglionic eminence late in the second trimester of development (23–24 weeks postconception). Cell organization in this region is heterogeneous along the ventricular wall, with GFAP-positive cells aligned to the ventricle. These cells coexpress markers for radial glia like GFAPδ, nestin, and vimentin. We also show the presence of abundant migratory neuroblasts in the anterior horn SVZ forming structures here denominated cell throngs. Interestingly, a ventral extension of the lateral ventricle suggests the presence of a putative RMS. Nevertheless, in the olfactory bulb neuroblast throngs or chain-like structures were not observed. The lack of these structures closer to the olfactory bulb could indicate a destination for the migratory neuroblasts outside the olfactory bulb in the human brain.
登录
查看更多内容
影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
DOI：
10.1016/j.devbrainres.2004.03.021
发表时间：
2004-07-19
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Bédard, A;Parent, A
通讯作者：
Parent, A
影响因子：
2.5
作者：
Brown, JP;Couillard-Després, S;Kuhn, HG
通讯作者：
Kuhn, HG
DOI：
10.1007/bf01098647
发表时间：
1972-01-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
BLAKEMORE, WF;JOLLY, RD
通讯作者：
JOLLY, RD
影响因子：
6.4
作者：
GERDES, J;SCHWAB, U;STEIN, H
通讯作者：
STEIN, H