Neuroendocrine regulation of maternal behavior.

Neuroendocrine regulation of maternal behavior.
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DOI:
10.1016/j.yfrne.2014.11.007
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发表时间:
2015-01
影响因子:
7.4
通讯作者:
Bridges, Robert S.
Bridges, Robert S.
中科院分区:
医学1区
文献类型:
--
作者:
Bridges, Robert S.

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哺乳动物母性行为的表达受雌性一生的发育和经验事件的调节。在这篇综述中,内分泌和神经系统之间的关系,在这些发展和经验中发挥关键作用,影响产妇护理的建立和维持。在啮齿类动物和高等哺乳动物中,在配体、受体和基因活性的背景下讨论了激素雌激素、孕激素和乳原的参与,在较小程度上讨论了高等哺乳动物的参与。阐述了神经内分泌因子,包括催产素、抗利尿激素、经典神经递质和其他调节产妇护理方面的神经基因产物的作用,并讨论了激素与中枢神经系统介质在产妇行为中的相互作用。先前的发育因素,包括表观遗传事件,以及母性经历对随后的母性护理的影响,在雌性的一生中进行评估。这是提出了共同的神经内分泌机制的基础上的母性护理哺乳动物的调节。
The expression of maternal behavior in mammals is regulated by the developmental and experiential events over a female’s lifetime. In this review the relationships between the endocrine and neural systems that play key roles in these developmental and experiential that affect both the establishment and maintenance of maternal care are presented. The involvement of the hormones estrogen, progesterone, and lactogens are discussed in the context of ligand, receptor, and gene activity in rodents and to a lesser extent in higher mammals. The roles of neuroendocrine factors, including oxytocin, vasopressin, classical neurotransmitters, and other neural gene products that regulate aspects of maternal care are set forth, and the interactions of hormones with central nervous system mediators of maternal behavior are discussed. The impact of prior developmental factors, including epigenetic events, and maternal experience on subsequent maternal care are assessed over the course of the female’s lifespan. It is proposed that common neuroendocrine mechanisms underlie the regulation of maternal care in mammals.
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