Immunological Relevance of the Coevolution of IDO1 and AHR.
Immunological Relevance of the Coevolution of IDO1 and AHR.
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DOI：
10.3389/fimmu.2014.00521
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发表时间：
2014
影响因子：
7.3
通讯作者：
Quintana FJ
中科院分区：
文献类型：
--
作者：
Jaronen M;Quintana FJ
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recently, AHR has been shown to play a crucial role in controlling innate and adaptive immune responses through several mechanisms, one of which is the regulation of tryptophan metabolism. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are considered rate-limiting enzymes in the tryptophan catabolism and play important roles in the regulation of the immunity. Moreover, AHR and IDO/TDO are closely interconnected: AHR regulates IDO and TDO expression, and kynurenine produced by IDO/TDO is an AHR agonist. In this review, we propose to examine the relationship between AHR and IDO/TDO and its relevance for the regulation of the immune response in health and disease.
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DOI：
10.1073/pnas.22.9.536
发表时间：
1936-01-01
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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影响因子：
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DOI：
10.1073/pnas.90.18.8566
发表时间：
1993-09-15
影响因子：
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作者：
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通讯作者：
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DOI：
10.1007/bf00334435
发表时间：
1971-01-01
期刊：
MOLECULAR AND GENERAL GENETICS
影响因子：
--
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通讯作者：
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