Synthesis of strontium substituted hydroxyapatite whiskers used as bioactive and mechanical reinforcement material

Synthesis of strontium substituted hydroxyapatite whiskers used as bioactive and mechanical reinforcement material
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用作生物活性和机械增强材料的锶取代羟基磷灰石晶须的合成

DOI:
10.1016/j.matlet.2011.11.093
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发表时间:
2012-03
期刊:
影响因子:
3
通讯作者:
Zhang, Weibin
Zhang, Weibin
中科院分区:
材料科学3区
文献类型:
--
作者:
Shen, Yuhui;Liu, Jinhao;Lin, Kaili;Zhang, Weibin

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采用均匀沉淀法合成了Sr取代6.6mol%Ca的羟基磷灰石(SrHA)晶须。产品的宽度为0.2-8μm,长度可达155μm。人成骨样细胞(MG-63)培养结果表明,在一定的提取浓度下,Sr置换可刺激MG-63细胞增殖。此外,加入SrHA晶须可以显着提高磷酸钙骨水泥(CPC)的机械性能。5wt.% SrHA晶须增强CPC的抗压强度最高,达到2.92MPa,比纯CPC提高了近2倍。我们的研究表明,SrHA晶须可能是一个潜在的候选人作为一种新的生物活性和机械增强材料的硬组织再生应用。
The strontium substituted hydroxyapatite (SrHA) whiskers with 6.6mol% of Ca replaced by Sr were successfully synthesized via homogeneous precipitation method. The product had a width of 0.2–8μm and length up to 155μm. The human osteoblast-like cell (MG-63) culture showed that Sr substitution could stimulate the proliferation of MG-63 at certain extracted concentrations. Furthermore, the addition of SrHA whiskers could significantly improve the mechanical properties of calcium phosphate cement (CPC). The 5wt.% SrHA whisker reinforced CPC revealed the highest compressive strength of 2.92MPa, which was almost 2-times higher than that of the pure CPC. Our study indicated that SrHA whisker might be a potential candidate as a new bioactive and mechanical reinforcement material for hard tissue regeneration applications.
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