High-dose methotrexate in combination with interferons in the treatment of malignant pleural mesothelioma.
High-dose methotrexate in combination with interferons in the treatment of malignant pleural mesothelioma.
复制标题
DOI：
10.1038/sj.bjc.6690597
复制
发表时间：
1999-08
影响因子：
8.8
通讯作者：
Mattson, K
中科院分区：
文献类型：
--
作者：
Halme, M;Knuuttila, A;Vehmas, T;Tammilehto, L;Mäntylä, M;Salo, J;Mattson, K
26例UICC I-IV期胸膜间皮瘤患者（不包括M1疾病）（其中46%为I期疾病，38%为III期疾病）接受了大剂量MTX（3 g）和亚叶酸钙静脉内急救治疗，间隔2周3次，间隔3周3次。每次MTX给药后皮下注射天然干扰素（IFN）-α（第2-10天3 MIU）和重组IFN-γ 1b（第2、6和10天50 μg m−2）。MTX治疗结束后，继续使用IFN作为维持治疗，直至疾病进展。在24例可评价缓解的患者中观察到7例部分缓解（缓解率29%，95%置信区间13-51%）。中位缓解持续时间为10个月（范围3-24个月）。中位生存期为17个月，1年和2年生存率分别为62%和31%。免疫化疗的毒副反应在可接受范围内。1例患者发生IV级神经毒性，停止治疗。MTX剂量减少是罕见的（2例患者发生1-2级肾毒性）。高剂量MTX与IFN-α和IFN-γ联合治疗对恶性胸膜间皮瘤有活性且耐受性良好。存活率令人鼓舞。© 1999癌症研究运动
Twenty six patients with pleural mesothelioma of UICC stage I–IV excluding M1 disease (46% of whom had stage I disease and 38% stage III disease) were treated intravenously with high dose MTX (3 g) and calcium folinate rescue three times at intervals of 2 weeks and three times at intervals of 3 weeks. Natural interferon (IFN)-α (3 MIU days 2–10) and recombinant IFN-γ 1b (50 μg m−2 on days 2, 6 and 10) were injected subcutaneously after each MTX dose. At the end of MTX treatment the IFNs were continued as maintenance therapy until disease progression. Seven partial responses were observed among 24 patients evaluable for response (response rate 29%, 95% confidence interval 13–51%). Median duration of response was 10 months (range 3–24 months). Median survival was 17 months and 1-year and 2-year survival rates 62% and 31% respectively. The toxicity of the chemo-immunotherapy was acceptable. Treatment was stopped in one patient who developed grade IV neurological toxicity. MTX dose reductions were rare (two patients with grade 1–2 renal toxicity). The combination of high dose MTX and IFN-α and IFN-γ is active against malignant pleural mesothelioma and well-tolerated. The survival rates are encouraging. © 1999 Cancer Research Campaign
登录
查看更多内容
影响因子：
9.6
作者：
Hunt, KJ;Longton, G;Livingston, RB
通讯作者：
Livingston, RB
影响因子：
5.8
作者：
OHNUMA, T;SZRAJER, L;MINOWADA, J
通讯作者：
MINOWADA, J
影响因子：
3.7
作者：
PASS, HW;TEMECK, BK;PASS, HI
通讯作者：
PASS, HI
影响因子：
5.3
作者：
STEWART, DJ;GERTLER, SZ;EVANS, WK
通讯作者：
EVANS, WK
影响因子：
6.4
作者：
ZENG, L;BUARD, A;JAURAND, MC
通讯作者：
JAURAND, MC