Visible Lights Combined with Photosensitizing Compounds Are Effective against Candida albicans Biofilms.
Visible Lights Combined with Photosensitizing Compounds Are Effective against Candida albicans Biofilms.
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DOI：
10.3390/microorganisms9030500
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发表时间：
2021-02-26
期刊：
影响因子：
4.5
通讯作者：
Nobile CJ
中科院分区：
文献类型：
--
作者：
Bapat P;Singh G;Nobile CJ
真菌感染在世界范围内的流行率正在增加，特别是在免疫功能低下的个体中。鉴于耐药真菌的出现以及只有三种主要类别的抗真菌药物可用于治疗侵袭性真菌感染的事实，需要开发有效对抗真菌感染的替代治疗策略。白色念珠菌是人类微生物群的一种，也是从临床环境中分离的最常见的真菌病原体之一。C.白念珠菌具有多种致病特性，包括形成耐药生物膜的能力，这可以使白念珠菌产生抗药性。在此，我们探索了单独的红色、绿色和蓝色可见光以及与普通光敏化合物组合的红色、绿色和蓝色可见光在抑制和破坏白色念珠菌感染方面的功效。白色念珠菌生物膜我们发现，蓝光抑制生物膜的形成，破坏成熟的生物膜本身，并增加光敏化合物提高其生物膜的潜力。然而，红色和绿色光仅与光敏化合物结合抑制生物膜形成，但对破坏成熟生物膜没有影响。综上所述，这些结果表明，光动力疗法可能是一种有效的非药物治疗真菌生物膜感染，值得进一步探索。
Fungal infections are increasing in prevalence worldwide, especially in immunocompromised individuals. Given the emergence of drug-resistant fungi and the fact that there are only three major classes of antifungal drugs available to treat invasive fungal infections, there is a need to develop alternative therapeutic strategies effective against fungal infections. Candida albicans is a commensal of the human microbiota that is also one of the most common fungal pathogens isolated from clinical settings. C. albicans possesses several virulence traits that contribute to its pathogenicity, including the ability to form drug-resistant biofilms, which can make C. albicans infections particularly challenging to treat. Here, we explored red, green, and blue visible lights alone and in combination with common photosensitizing compounds for their efficacies at inhibiting and disrupting C. albicans biofilms. We found that blue light inhibited biofilm formation and disrupted mature biofilms on its own and that the addition of photosensitizing compounds improved its antibiofilm potential. Red and green lights, however, inhibited biofilm formation only in combination with photosensitizing compounds but had no effects on disrupting mature biofilms. Taken together, these results suggest that photodynamic therapy may be an effective non-drug treatment for fungal biofilm infections that is worthy of further exploration.
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影响因子：
3.3
作者：
Dai, Tianhong;Huang, Ying-Ying;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
4.9
作者：
Dai, Tianhong;de Arce, Vida J. Bil;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
影响因子：
--
作者：
Dai, Tianhong;Gupta, Asheesh;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
影响因子：
2.1
作者：
Briggs T;Blunn G;Hislop S;Ramalhete R;Bagley C;McKenna D;Coathup M
通讯作者：
Coathup M