Individualized medicine and the microbiome in reproductive tract.
Individualized medicine and the microbiome in reproductive tract.
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DOI：
10.3389/fphys.2015.00097
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发表时间：
2015
影响因子：
4
通讯作者：
White BA
中科院分区：
文献类型：
--
作者：
Braundmeier AG;Lenz KM;Inman KS;Chia N;Jeraldo P;Walther-António MR;Berg Miller ME;Yang F;Creedon DJ;Nelson H;White BA
人类沿着着数百万种微生物在其体内繁衍进化。这些微生物（1014个）的数量是人类细胞的10比1，拥有3 × 106个基因，是25，000个人类基因的十倍多。这种微生物宏基因组充当我们的“其他基因组”，就像我们自己的基因一样，对个体来说是独一无二的。最近的国际努力，如人类微生物组计划（HMP）和MetaHIT项目，已经帮助使用非培养、高通量、下一代测序对这些微生物基因组进行了编目。这篇手稿将描述最近的努力，以确定微生物多样性在女性生殖道，因为微生物的功能对生殖效率的影响。在这篇综述中，我们将讨论目前的证据表明，微生物群落对维持生殖健康至关重要，以及微生物群落结构的扰动如何从感染，生殖周期，怀孕和疾病状态等方面影响生殖健康。对人类微生物组的研究正在推动从治疗医学人群到治疗个体患者的干预策略。特别是，我们强调如何理解和定义不同疾病和生理状态下的微生物群落结构，从而发现生物标志物，更重要的是，微生物干预策略（益生菌）的开发和实施进入现代医学。最后，本综述将总结在动物和人类疾病模型中实施的微生物干预策略的有效性，以及将这些微生物干预策略整合到标准临床实践中的潜力。
Humans have evolved along with the millions of microorganisms that populate their bodies. These microbes (1014) outnumber human cells by 10 to 1 and account for 3 × 106 genes, more than ten times the 25,000 human genes. This microbial metagenome acts as our “other genome” and like our own genes, is unique to the individual. Recent international efforts such as the Human Microbiome Project (HMP) and the MetaHIT Project have helped catalog these microbial genomes using culture-independent, high-throughput, next-generation sequencing. This manuscript will describe recent efforts to define microbial diversity in the female reproductive tract because of the impact that microbial function has on reproductive efficiency. In this review, we will discuss current evidence that microbial communities are critical for maintaining reproductive health and how perturbations of microbial community structures can impact reproductive health from the aspect of infection, reproductive cyclicity, pregnancy, and disease states. Investigations of the human microbiome are propelling interventional strategies from treating medical populations to treating individual patients. In particular, we highlight how understanding and defining microbial community structures in different disease and physiological states have lead to the discovery of biomarkers and, more importantly, the development and implementation of microbial intervention strategies (probiotics) into modern day medicine. Finally this review will conclude with a literature summary of the effectiveness of microbial intervention strategies that have been implemented in animal and human models of disease and the potential for integrating these microbial intervention strategies into standard clinical practice.
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影响因子：
2.1
作者：
Donders, G. G. G.;Van Bulck, B.;Graf, F.
通讯作者：
Graf, F.
DOI：
10.1086/657320
发表时间：
2010-12-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Brotman RM;Klebanoff MA;Nansel TR;Yu KF;Andrews WW;Zhang J;Schwebke JR
通讯作者：
Schwebke JR
影响因子：
3.7
作者：
Aagaard K;Riehle K;Ma J;Segata N;Mistretta TA;Coarfa C;Raza S;Rosenbaum S;Van den Veyver I;Milosavljevic A;Gevers D;Huttenhower C;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
3.8
作者：
Doyle, R. M.;Alber, D. G.;Klein, N.
通讯作者：
Klein, N.
影响因子：
4.2
作者：
Dabek, Marta;McCrae, Sheila I.;Louis, Petra
通讯作者：
Louis, Petra