Establishing reference intervals for bone turnover markers in the healthy shanghai population and the relationship with bone mineral density in postmenopausal women.
Establishing reference intervals for bone turnover markers in the healthy shanghai population and the relationship with bone mineral density in postmenopausal women.
复制标题
建立上海健康人群骨转换指标参考区间及其与绝经后女性骨矿物质密度的关系
DOI：
10.1155/2013/513925
复制
发表时间：
2013
影响因子：
2.8
通讯作者：
Zhang ZL
中科院分区：
文献类型：
--
作者：
Hu WW;Zhang Z;He JW;Fu WZ;Wang C;Zhang H;Yue H;Gu JM;Zhang ZL
骨转换标志物（BTM）的参考范围在骨质疏松症的治疗中非常重要，但其与骨密度（BMD）的关系存在争议。本研究旨在建立上海地区绝经后妇女骨钙素（OC）、I型胶原N端前胶原（P1 NP）和I型胶原β-C端交联端肽（β-CTX）的正常参考值范围，并探讨骨钙素与骨密度的关系。对上海市2，799名受试者进行了BTM测定，建立了BTM的参考范围。另外520名健康绝经后妇女也进行了BTM测量，这些妇女还测量了BMD。使用Roche电化学发光系统测量BTM。我们使用35至45岁的年龄范围来计算参考区间。OC的参考范围为女性4.91 - 13.90 ng/mL和男性5.58 - 16.57 ng/mL，P1 NP为女性13.72 - 32.90 ng/mL和男性16.89 - 42.43 ng/mL，β-CTX为女性0.112 - 0.210 ng/mL和男性0.100 - 0.378 ng/mL。绝经后女性BTM与腰椎、股骨和全髋呈显著负相关（Betastd =-0.157 ~-0.217，P < 0.001）。建立了上海地区P1 NP、OC、β-CTX正常参考值范围。本研究还发现BTM与BMD相关，并提示BTM是早期BMD降低的关键决定因素。
The reference ranges of bone turnover markers (BTMs) were important during the treatment of osteoporosis, and the associations with bone mineral density (BMD) were controversial. The aim of this study was to establish the reference ranges of N-terminal procollagen of type l collagen (P1NP), osteocalcin (OC), and beta C-terminal cross-linked telopeptides of type I collagen (β-CTX) in Shanghai area and to investigate the relationships between BTMs and BMD in postmenopausal women. 2,799 subjects recruited in Shanghai City were measured BTMs to establish the reference ranges. Additional 520 healthy postmenopausal women were also measured BTMs, these women measured BMD in addition. BTMs were measured using the Roche electrochemiluminescence system. We used the age range of 35 to 45-year-olds to calculate reference intervals. The reference range of OC was 4.91 to 13.90 ng/mL for women and 5.58 to 16.57 ng/mL for men, P1NP was 13.72 to 32.90 ng/mL for women and 16.89 to 42.43 ng/mL for men, and β-CTX was 0.112 to 0.210 ng/mL for women and 0.100 to 0.378 ng/mL for men. BTMs significantly negatively correlated with lumbar spine and femoral and total hip in postmenopausal women (Betastd = −0.157 ~ −0.217, P < 0.001). We established the normal reference ranges of P1NP, OC, and β-CTX in the Shanghai area. This study also found that BTMs correlated with BMD and suggested that BTMs were the key determining factors of early BMD decreases.
登录
查看更多内容
影响因子：
6.2
作者：
Eastell, R;Barton, I;Delmas, PD
通讯作者：
Delmas, PD
影响因子：
6.2
作者：
Chiu, KM;Ju, J;Arnaud, CD
通讯作者：
Arnaud, CD
影响因子：
4.1
作者：
Gundberg, CM;Looker, AC;Calvo, MS
通讯作者：
Calvo, MS
影响因子：
6.2
作者：
Glover, Sarah J.;Gall, Martin;Eastell, Richard
通讯作者：
Eastell, Richard
影响因子：
3.2
作者：
WISHART, JM;NEED, AG;NORDIN, BEC
通讯作者：
NORDIN, BEC