Glaucomatous Visual Field Progression in the African Descent and Glaucoma Evaluation Study (ADAGES): Eleven Years of Follow-up.
Glaucomatous Visual Field Progression in the African Descent and Glaucoma Evaluation Study (ADAGES): Eleven Years of Follow-up.
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DOI：
10.1016/j.ajo.2022.02.003
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发表时间：
2022-07
影响因子：
4.2
通讯作者：
Liebmann, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Melchior, Bruna;Valenzuela, Ives A.;de Moraes, C. Gustavo;Paula, Jayter S.;Fazio, Massimo A.;Girkin, Christopher A.;Proudfoot, James;Cioffi, George A.;Weinreb, Robert N.;Zangwill, Linda M.;Liebmann, Jeffrey M.
To compare the rates of visual field (VF) progression between individuals of Black and White race and to investigate whether treatment effects may help explain differences previously reported between racial groups. Multicenter prospective observational cohort study. Participants with open angle glaucoma excluding those that had < 5 VF tests and < 2 years of follow-up, or any disease that could affect the optic nerve or the VF. The VF mean deviation (MD) slopes over time (dB/year) were calculated with linear regression models. We investigated socioeconomic (SE) variables, rates of glaucoma surgery, medications, treated intraocular pressure (IOP), and central corneal thickness (CCT). Tertiary care glaucoma clinics. A total of 516 eyes were included with a mean (95% CI) follow-up time of 11.0 (10.5 to 11.5) years and 15.0 (14.1 to 15.8) visits. Participants of Black race were significantly younger (59.7 vs 66.9 years old, P < 0.01). The mean CCT and SE variables were similar between Black and White groups (P = 0.21 and P = 0.56, respectively), as were treatment with topical medications (P = 0.90) and the rate of VF MD change (−0.24 [−0.31 to −0.17] dB/year vs −0.32 [−0.36 to −0.27], P= 0.11), despite higher treated mean IOP (14.9 [14.5 to 15.4] vs 14.0 [13.6 to 14.4] mmHg, P=0.03) and fewer trabeculectomies (29.5% vs 50.0%, p < 0.01) in the Black race group. Rates of VF progression were similar despite higher treated IOP in the Black race group. Mitigation of health access disparities in this study may have equalized previously reported different rates of VF progression between racial groups. It has been postulated that socioeconomic differences between individuals of Black and White race may affect glaucoma progression. This article aimed to compare the rates of visual field progression between them and to investigate whether treatment effects may help explain differences previously reported between racial groups. Mitigation of health access disparities in this study may have equalized previously reported different rates of visual field progression between racial groups.
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影响因子：
--
作者：
Higginbotham, EJ;Gordon, MO;Kass, MA
通讯作者：
Kass, MA
影响因子：
4.2
作者：
Khachatryan, Naira;Medeiros, Felipe A.;Zangwill, Linda M.
通讯作者：
Zangwill, Linda M.
影响因子：
--
作者：
LESKE, MC;CONNELL, AMS;HYMAN, L
通讯作者：
HYMAN, L
DOI：
10.1001/jama.2014.3192
发表时间：
2014-05-14
期刊：
JAMA
影响因子：
--
作者：
Weinreb RN;Aung T;Medeiros FA
通讯作者：
Medeiros FA
影响因子：
13.7
作者：
Tham, Yih-Chung;Li, Xiang;Cheng, Ching-Yu
通讯作者：
Cheng, Ching-Yu