Functional organization and restoration of the brain motor-execution network after stroke and rehabilitation.
Functional organization and restoration of the brain motor-execution network after stroke and rehabilitation.
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DOI：
10.3389/fnhum.2015.00173
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发表时间：
2015
影响因子：
2.9
通讯作者：
Dhamala M
中科院分区：
文献类型：
--
作者：
Bajaj S;Butler AJ;Drake D;Dhamala M
人脑运动系统的多个皮层区域在低频范围（<0.1 Hz）内连贯地相互作用，即使在没有明确任务的情况下也是如此。中风后，皮质的相互作用在功能上受到干扰。当人们开始恢复运动行为时，这些相互作用是如何受到影响的，以及功能组织是如何从康复治疗中恢复的，还没有系统的研究。我们记录了30名参与者的内在功能磁共振成像（fMRI）信号：17名年轻健康对照组和13名老年卒中幸存者。中风参与者在中风后14-51天内接受心理练习（MP）或心理练习和物理治疗（MP+PT）。我们研究了运动执行网络中的五个核心区域的网络活动，包括左主运动区（LM 1），右主运动区（RM 1），左前运动区（LPMC），右前运动区（RPMC）和辅助运动区（SMA）。我们发现，（i）网络活动在所有区域的频率范围0.06-0.08 Hz内占主导地位，并且对于健全和中风参与者（ii）区域之间的因果信息流：LM 1和SMA，RPMC和SMA，RPMC和LM 1，SMA和RM 1，SMA和LPMC，（iii）单独MP后血流没有显著增加，（iv）MP+PT期间各区域间的血流显著增加。我们还发现，当中风幸存者接受MP+PT而不是单独接受MP时，感觉和运动评分显着更高，并且与定向功能连接测量相关。这些发现提供了证据，表明心理练习和物理治疗的结合可以成为中风幸存者恢复或恢复运动行为强度的有效治疗手段，并且因果信息流的频谱可以用作评估中风幸存者康复的可靠生物标志物。
Multiple cortical areas of the human brain motor system interact coherently in the low frequency range (<0.1 Hz), even in the absence of explicit tasks. Following stroke, cortical interactions are functionally disturbed. How these interactions are affected and how the functional organization is regained from rehabilitative treatments as people begin to recover motor behaviors has not been systematically studied. We recorded the intrinsic functional magnetic resonance imaging (fMRI) signals from 30 participants: 17 young healthy controls and 13 aged stroke survivors. Stroke participants underwent mental practice (MP) or both mental practice and physical therapy (MP+PT) within 14–51 days following stroke. We investigated the network activity of five core areas in the motor-execution network, consisting of the left primary motor area (LM1), the right primary motor area (RM1), the left pre-motor cortex (LPMC), the right pre-motor cortex (RPMC) and the supplementary motor area (SMA). We discovered that (i) the network activity dominated in the frequency range 0.06–0.08 Hz for all the regions, and for both able-bodied and stroke participants (ii) the causal information flow between the regions: LM1 and SMA, RPMC and SMA, RPMC and LM1, SMA and RM1, SMA and LPMC, was reduced significantly for stroke survivors (iii) the flow did not increase significantly after MP alone and (iv) the flow among the regions during MP+PT increased significantly. We also found that sensation and motor scores were significantly higher and correlated with directed functional connectivity measures when the stroke-survivors underwent MP+PT but not MP alone. The findings provide evidence that a combination of mental practice and physical therapy can be an effective means of treatment for stroke survivors to recover or regain the strength of motor behaviors, and that the spectra of causal information flow can be used as a reliable biomarker for evaluating rehabilitation in stroke survivors.
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影响因子：
3
作者：
Bajaj S;Drake D;Butler AJ;Dhamala M
通讯作者：
Dhamala M
影响因子：
3.7
作者：
Bajaj S;Adhikari BM;Dhamala M
通讯作者：
Dhamala M
影响因子：
3.7
作者：
Gerardin, E;Sirigu, A;Le Bihan, D
通讯作者：
Le Bihan, D
影响因子：
2.9
作者：
Dum, RP;Strick, PL
通讯作者：
Strick, PL
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.