Orientation of Cell Polarity by Chemical Gradients.
Orientation of Cell Polarity by Chemical Gradients.
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DOI：
10.1146/annurev-biophys-110821-071250
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发表时间：
2022-05-09
影响因子：
12.4
通讯作者：
Lew, Daniel
中科院分区：
文献类型：
--
作者：
Ghose, Debraj;Elston, Timothy;Lew, Daniel
准确解码空间化学景观对许多细胞功能至关重要。真核细胞解码局部化学梯度，使生长或运动向生产方向方向。酵母模型系统的梯度感应通路比动物细胞的要简单得多，最近对酵母模型系统的研究为这些非常小的细胞如何成功地利用嘈杂和动态信息素梯度中的信息来识别它们的配偶提供了新的范例。信息素受体调节以保守的rho家族GTPase Cdc42为中心的极性回路。极性电路包含正负反馈通路，允许自发的对称性破坏和极性位点的拆卸和重新定位。Cdc42定向肌动蛋白细胞骨架，导致聚焦的囊泡交通，促进极性位点的运动，并重塑细胞表面受体的皮质分布。在此，我们回顾了酵母的研究进展，并与趋化动物细胞中发现的可兴奋信号通路进行了比较。
Accurate decoding of spatial chemical landscapes is critical for many cell functions. Eukaryotic cells decode local chemical gradients to orient growth or movement in productive directions. Recent work on yeast model systems, whose gradient sensing pathways display much less complexity than those in animal cells, has suggested new paradigms for how these very small cells successfully exploit information in noisy and dynamic pheromone gradients to identify their mates. Pheromone receptors regulate a polarity circuit centered on the conserved Rho-family GTPase, Cdc42. The polarity circuit contains both positive and negative feedback pathways, allowing spontaneous symmetry breaking and also polarity site disassembly and relocation. Cdc42 orients the actin cytoskeleton, leading to focused vesicle traffic that promotes movement of the polarity site and also reshapes the cortical distribution of receptors at the cell surface. Here, we review the advances from yeasts and compare with the excitable signaling pathways that have been revealed in chemotactic animal cells.
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影响因子：
56.9
作者：
Butty, AC;Pryciak, PM;Peter, M
通讯作者：
Peter, M
DOI：
10.1074/jbc.r116.714980
发表时间：
2016-04-08
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Alvaro CG;Thorner J
通讯作者：
Thorner J
影响因子：
8
作者：
Artemenko, Yulia;Lampert, Thomas J.;Devreotes, Peter N.
通讯作者：
Devreotes, Peter N.
影响因子：
4.8
作者：
Endo, M;Shirouzu, M;Yokoyama, S
通讯作者：
Yokoyama, S
影响因子：
21.3
作者：
Andrew, Natalie;Insall, Robert H.
通讯作者：
Insall, Robert H.