Roles of nucleus accumbens and basolateral amygdala in autoshaped lever pressing.
Roles of nucleus accumbens and basolateral amygdala in autoshaped lever pressing.
复制标题
伏隔核和基底外侧杏仁核的作用在Autoshaped Lever按压中。
DOI：
10.1016/j.nlm.2012.03.008
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发表时间：
2012-05
影响因子：
2.7
通讯作者：
Holland, Peter C.
中科院分区：
文献类型：
--
作者：
Chang, Stephen E.;Wheeler, Daniel S.;Holland, Peter C.
最初中性的线索与奖励相结合被认为具有激励意义，就好像奖励的激励价值转移到了线索上一样。这些线索可以作为次要强化物来建立新的学习，调节工具性行为的表现（巴甫洛夫工具转移，PIT），并成为方法和其他线索导向行为的目标。在这里，我们研究了腹侧纹状体伏隔核（ACb）和基底外侧杏仁核（BLA）的损伤对大鼠获得辨别性自形杠杆按压的影响。蔗糖输送增强了一个杠杆插入实验室的效果，但另一杠杆的插入则没有增强。尽管蔗糖的输送与大鼠的行为无关，但假损伤的大鼠很快就会按压加固杠杆，而不是非加固杠杆。双侧 ACb 损伤损害了体征追踪的初始获取，但不影响其最终水平。相比之下，BLA 损伤在体征追踪的末端水平产生了显着的缺陷。此外，ACb 损伤主要影响杠杆按压反应的概率，而 BLA 损伤主要影响发生后的反应率。最后，破坏 ACb 和 BLA 之间通讯的断开损伤产生了两组缺陷。我们认为，ACb 对于最初获得包含奖励的享乐方面的完美反应非常重要，而 BLA 在获得后有助于增强这种激励的显着性。
Initially-neutral cues paired with rewards are thought to acquire motivational significance, as if the incentive motivational value of the reward is transferred to the cue. Such cues may serve as secondary reinforcers to establish new learning, modulate the performance of instrumental action (Pavlovian-instrumental transfer, PIT), and be the targets of approach and other cue-directed behaviors. Here we examined the effects of lesions of the ventral striatal nucleus accumbens (ACb) and the basolateral amygdala (BLA) on the acquisition of discriminative autoshaped lever-pressing in rats. Insertion of one lever into the experimental chamber was reinforced by sucrose delivery, but insertion of another lever was not reinforced. Although sucrose was delivered independently of the rats’ behavior, sham-lesioned rats rapidly came to press the reinforced but not the nonreinforced lever. Bilateral ACb lesions impaired the initial acquisition of sign-tracking but not its terminal levels. In contrast, BLA lesions produced substantial deficits in terminal levels of sign-tracking. Furthermore, whereas ACb lesions primarily affected the probability of lever press responses, BLA lesions mostly affected the rate of responding once it occurred. Finally, disconnection lesions that disrupted communication between ACb and BLA produced both sets of deficits. We suggest that ACb is important for initial acquisition of consummatory-like responses that incorporate hedonic aspects of the reward, while BLA serves to enhance such incentive salience once it is acquired.
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影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
7.6
作者：
Flagel, Shelly B.;Robinson, Terry E.;Clark, Jeremy J.;Clinton, Sarah M.;Watson, Stanley J.;Seeman, Phillip;Phillips, Paul E. M.;Akil, Huda
通讯作者：
Akil, Huda
影响因子：
2.7
作者：
Flagel, Shelly B.;Watson, Stanley J.;Robinson, Terry E.
通讯作者：
Robinson, Terry E.
影响因子：
1.9
作者：
Bussey, TJ;Everitt, BJ;Robbins, TW
通讯作者：
Robbins, TW
DOI：
10.1016/s0079-7421(00)80022-5
发表时间：
2001-01-01
期刊：
PSYCHOLOGY OF LEARNING AND MOTIVATION: ADVANCES IN RESEARCH AND THEORY, VOL 40
影响因子：
--
作者：
Berridge, KC
通讯作者：
Berridge, KC