At the limbic-motor interface: disconnection of basolateral amygdala from nucleus accumbens core and shell reveals dissociable components of incentive motivation.
At the limbic-motor interface: disconnection of basolateral amygdala from nucleus accumbens core and shell reveals dissociable components of incentive motivation.
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DOI：
10.1111/j.1460-9568.2010.07439.x
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Balleine BW
中科院分区：
文献类型：
--
作者：
Shiflett MW;Balleine BW
尽管伏隔核（NAc）长期以来被假设为边缘区和运动区之间的接口，但缺乏这种对行为调节作用的直接证据。使用大鼠的断开程序，我们发现基底外侧杏仁核（BLA）输入到NAc的核心和内侧壳分别介导两个不同的激励过程，分别控制目标导向的工具性行动的表现：（1）工具性响应对目标或结果的经验值变化的敏感性，由特定的饱腹感引起的结果贬值产生，以及（2）奖励相关线索对行动选择的影响，在结果特异性中观察到巴甫洛夫乐器转移。因此，这些结果表明，涉及 NAc 核心和内侧壳 BLA 输入的可分离神经回路介导了控制工具调节中选择和决策的激励激励过程的不同组成部分。
Although the nucleus accumbens (NAc) has long been hypothesized to act as an interface between limbic and motor regions, direct evidence for this modulatory role on behavior is lacking. Using a disconnection procedure in rats, we found that basolateral amygdala (BLA) input to the core and medial shell of the NAc separately mediate two distinct incentive processes controlling the performance of goal-directed, instrumental actions, respectively: (1) the sensitivity of instrumental responding to changes in the experienced value of the goal or outcome, produced by specific satiety-induced outcome devaluation, and (2) the effect of reward-related cues on action selection, observed in outcome-specific Pavlovian-instrumental transfer. These results reveal, therefore, that dissociable neural circuits involving BLA inputs to the NAc core and medial shell mediate distinct components of the incentive motivational processes controlling choice and decision-making in instrumental conditioning.
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DOI：
10.1038/npp.2009.187
发表时间：
2010-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
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作者：
通讯作者：
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影响因子：
3.3
作者：
EVERITT, BJ;MORRIS, KA;ROBBINS, TW
通讯作者：
ROBBINS, TW
影响因子：
5.3
作者：
Floresco, SB;Ghods-Sharifi, S;Magyar, O
通讯作者：
Magyar, O
影响因子：
5.3
作者：
Dwyer, Dominic M.;Killcross, Simon
通讯作者：
Killcross, Simon
影响因子：
5.3
作者：
Floresco, SB;Blaha, CD;Phillips, AG
通讯作者：
Phillips, AG