Immune Function and Muscle Adaptations to Resistance exercise in Older Adults: Study Protocol for a Randomized Controlled Trial of a Nutritional Supplement.
Immune Function and Muscle Adaptations to Resistance exercise in Older Adults: Study Protocol for a Randomized Controlled Trial of a Nutritional Supplement.
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DOI：
10.1186/s13063-015-0631-3
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发表时间：
2015-03-27
期刊：
影响因子：
2.5
通讯作者：
Sullivan DH
中科院分区：
文献类型：
--
作者：
Dennis RA;Ponnappan U;Kodell RL;Garner KK;Parkes CM;Bopp MM;Padala KP;Peterson CA;Padala PR;Sullivan DH
免疫功能可能会影响老年人在衰老过程中保持或改善肌肉质量、力量和功能的能力。因此，支持免疫系统的营养补充剂可以补充抵抗力运动，作为对与年龄相关的肌肉损失的干预。目前的研究将确定在抵抗训练和训练后随访期间服用营养补充剂或安慰剂的老年人的免疫功能和运动训练结果之间的关系。之所以选择这种补充剂，是因为有证据表明其成分[精氨酸(Arg)、谷氨酰胺(Gln)和β-羟基β-甲基丁酸酯(HMB)]可以提高免疫功能，促进肌肉生长，并抵消肌肉损失。美国军队退伍军人(60岁至80岁，N = 50岁)将参加一项随机双盲安慰剂对照试验，在完成三个研究目标期间食用营养补充剂或安慰剂：1)确定2周的补充剂是否改善了免疫功能，以衡量对疫苗接种的反应以及对急性阻力运动的系统和细胞反应；2)确定36次阻力训练期间的补充剂是否促进了肌肉大小、力量和功能的增加；以及3)确定训练后持续26周的补充剂是否能促进保持训练引起的肌肉大小、力量和功能上的增加。对这些目标结果的分析将确定免疫功能和训练结果之间的关系。参与者将接受9次抽血和5次股外侧肌活组织检查，以衡量补充剂对免疫功能以及对运动的系统和细胞反应的影响。众所周知，运动对免疫功能有影响。然而，这项研究将尝试使用营养补充剂来调节免疫功能，并确定对训练结果的影响。这项研究还将检查训练后的福利保留，这对老年人来说是一个重要的问题，通常在运动研究中被省略。这项研究可能会促进我们对老年人肌肉增减机制的理解，但更重要的是，营养干预将被评估为支持衰老期间肌肉健康的锻炼的补充。ClinicalTrials.gov标识符：NCT02261961，注册日期2014年6月10日，招聘活跃。
Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will determine the relationship between immune function and exercise training outcomes for older adults who consume a nutritional supplement or placebo during resistance training and post-training follow-up. The supplement was chosen due to evidence suggesting its ingredients [arginine (Arg), glutamine (Gln), and β-hydroxy β-methylbutyrate (HMB)] can improve immune function, promote muscle growth, and counteract muscle loss. Veterans (age 60 to 80 yrs, N = 50) of the United States military will participate in a randomized double-blind placebo-controlled trial of consumption of a nutritional supplement or placebo during completion of three study objectives: 1) determine if 2 weeks of supplementation improve immune function measured as the response to vaccination and systemic and cellular responses to acute resistance exercise; 2) determine if supplementation during 36 sessions of resistance training boosts gains in muscle size, strength, and function; and 3) determine if continued supplementation for 26 weeks post-training promotes retention of training-induced gains in muscle size, strength, and function. Analyses of the results for these objectives will determine the relationship between immune function and the training outcomes. Participants will undergo nine blood draws and five muscle (vastus lateralis) biopsies so that the effects of the supplement on immune function and the systemic and cellular responses to exercise can be measured. Exercise has known effects on immune function. However, the study will attempt to modulate immune function using a nutritional supplement and determine the effects on training outcomes. The study will also examine post-training benefit retention, an important issue for older adults, usually omitted from exercise studies. The study will potentially advance our understanding of the mechanisms of muscle gain and loss in older adults, but more importantly, a nutritional intervention will be evaluated as a complement to exercise for supporting muscle health during aging. Clinicaltrials.gov identifier: NCT02261961, registration date 10 June 2014, recruitment active.
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影响因子：
11.8
作者：
Halperin, B. A.;Morris, A.;Halperin, S. A.
通讯作者：
Halperin, S. A.
DOI：
10.1016/j.apmr.2012.01.014
发表时间：
2012-07-01
影响因子：
4.3
作者：
Hiengkaew, Vimonwan;Jitaree, Khanitha;Chaiyawat, Pakaratee
通讯作者：
Chaiyawat, Pakaratee
DOI：
10.1111/j.1439-0396.2008.00833.x
发表时间：
2009-08-01
影响因子：
2.7
作者：
Buyse, J.;Swennen, Q.;Goddeeris, B. M.
通讯作者：
Goddeeris, B. M.
影响因子：
4.6
作者：
Dennis, Richard A.;Zhu, Haiyan;Peterson, Charlotte A.
通讯作者：
Peterson, Charlotte A.
影响因子：
3.3
作者：
Cantini, M;Giurisato, E;Vitiello, L
通讯作者：
Vitiello, L