Depressive-like behavioral response of adult male rhesus monkeys during routine animal husbandry procedure.
Depressive-like behavioral response of adult male rhesus monkeys during routine animal husbandry procedure.
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成年雄性恒河猴在常规畜牧业过程中的抑郁样行为反应。
DOI：
10.3389/fnbeh.2014.00309
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发表时间：
2014
影响因子：
3
通讯作者：
Capitanio JP
中科院分区：
文献类型：
--
作者：
Hennessy MB;McCowan B;Jiang J;Capitanio JP
社会孤立是抑郁症发展的主要危险因素;然而，没有实用的非人灵长类动物模型可用于研究这种影响所涉及的过程。在第一项研究中，我们注意到，单独圈养在室内的成年雄性恒河猴偶尔会表现出驼背、抑郁样的姿势。因此，研究2调查了成年男性从室外社会群体带到室内个人住房的驼背姿势的发生。我们还对另外两种行为进行了评分躺在地板上和白天睡觉传达了抑郁的印象。在单独圈养后的第一周观察期间，26只成年雄性中有18只表现出弓背姿势，26只中有21只表现出至少一种抑郁样行为。在2周内，26只雄性中有23只在总共仅20分钟的观察期间表现出抑郁样行为。此外，在第一周的行为呈正相关的水平，最初的反应，在婴儿期经历的母亲分离程序。在研究3中，在单独圈养的第7-14周的每个10分钟观察期间，新样本的23只成年雄性动物中超过一半表现出抑郁样行为。研究2和3中令人惊讶的高频率抑郁样行为可能是由于通过相机记录行为，房间里没有人引起竞争反应。这些结果表明，一个共同的畜牧业程序可能提供了一个实用的方法来检查社会隔离对抑郁症相关的终点在非人灵长类动物的影响。研究结果还表明，婴儿期分离期间情绪反应的特质差异可能预测成年后社会隔离期间反应的差异。
Social isolation is a major risk factor for the development of depressive illness; yet, no practical nonhuman primate model is available for studying processes involved in this effect. In a first study, we noted that adult male rhesus monkeys housed individually indoors occasionally exhibited a hunched, depressive-like posture. Therefore, Study 2 investigated the occurrence of a hunched posture by adult males brought from outdoor social groups to indoor individual housing. We also scored two other behaviors—lying on the substrate and day time sleeping—that convey an impression of depression. During the first week of observation following individual housing, 18 of 26 adult males exhibited the hunched posture and 21 of 26 displayed at least one depressive-like behavior. Over 2 weeks, 23 of 26 males showed depressive-like behavior during a total of only 20 min observation. Further, the behavior during the first week was positively related to the level of initial response to a maternal separation procedure experienced in infancy. In Study 3, more than half of 23 adult males of a new sample displayed depressive-like behavior during 10 min of observation each of Weeks 7–14 of individual housing. The surprisingly high frequency of depressive-like behavior in Studies 2 and 3 may have been due to recording behavior via camera with no human in the room to elicit competing responses. These results suggest that a common animal husbandry procedure might provide a practical means for examining effects of social isolation on depression-related endpoints in a nonhuman primate. The findings also suggest that trait-like differences in emotional responsiveness during separation in infancy may predict differences in responsiveness during social isolation in adulthood.
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影响因子：
3
作者：
Camus SM;Rochais C;Blois-Heulin C;Li Q;Hausberger M;Bezard E
通讯作者：
Bezard E
影响因子：
3.7
作者：
Camus SM;Blois-Heulin C;Li Q;Hausberger M;Bezard E
通讯作者：
Bezard E
影响因子：
3.7
作者：
Li X;Xu F;Xie L;Ji Y;Cheng K;Zhou Q;Wang T;Shively C;Wu Q;Gong W;Fang L;Zhan Q;Melgiri ND;Xie P
通讯作者：
Xie P
影响因子：
3.7
作者：
Dantzer, Robert;O'Connor, Jason C.;Lawson, Marcus A.;Kelley, Keith W.
通讯作者：
Kelley, Keith W.
DOI：
10.1111/j.1467-8721.2007.00481.x
发表时间：
2007-04-01
影响因子：
7.2
作者：
Gillespie, Charles F.;Nemeroff, Charles B.
通讯作者：
Nemeroff, Charles B.