Depression-like behavioral phenotypes by social and social plus visual isolation in the adult female Macaca fascicularis.
Depression-like behavioral phenotypes by social and social plus visual isolation in the adult female Macaca fascicularis.
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DOI：
10.1371/journal.pone.0073293
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Xie P
中科院分区：
文献类型：
--
作者：
Li X;Xu F;Xie L;Ji Y;Cheng K;Zhou Q;Wang T;Shively C;Wu Q;Gong W;Fang L;Zhan Q;Melgiri ND;Xie P
重度抑郁症（MDD）是一种使人衰弱的精神情绪障碍，影响全球数百万人。我们对MDD的生物学基础的理解很差，目前的治疗在很大一部分病例中是无效的。这种现状可能与抑郁症的主要啮齿动物模型有关，由于与人类的同源性有限，这些模型具有翻译限制。因此，需要一个更同源的灵长类抑郁症模型，以推进对抑郁症的病理生理机制的调查，并进行临床前治疗试验。在这里，我们报告了两种方便的方法-社会隔离和社会加视觉隔离-这可以应用于构建一个非人灵长类动物抑郁症模型的成年雌性食蟹猴（食蟹猴）。社会和社会加上视觉隔离被证明是有效的诱导抑郁样行为显着减少社会主导的攻击性冲突行为，沟通行为，性行为，和父母的行为。视觉隔离的增加比单独的社会隔离产生了更深刻的行为变化，进一步减少了父母行为和性行为。因此，行为病理学的程度可以通过隔离的程度来操纵。这些方法可以应用于构建一个非人灵长类动物抑郁症模型，以评估生理，行为和社会现象，在受控的实验室设置。
Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the dominant rodent animal models of depression, which possess translational limitations due to limited homologies with humans. Therefore, a more homologous primate model of depression is needed to advance investigation into the pathophysiological mechanisms underlying depression and to conduct pre-clinical therapeutic trials. Here, we report two convenient methods – social isolation and social plus visual isolation – which can be applied to construct a non-human primate model of depression in the adult female cynomolgus monkey (Macaca fascicularis). Both social and social plus visual isolation were shown to be effective in inducing depression-like behavior by significantly reducing socially dominant aggressive conflict behavior, communicative behavior, sexual behavior, and parental behavior. The addition of visual isolation produced more profound behavioral changes than social isolation alone by further reducing parental behavior and sexual behavior. Thus, the degree of behavioral pathology may be manipulated by the degree of isolation. These methods can be applied to construct a non-human primate model of depression in order to assess physiological, behavioral, and social phenomena in a controlled laboratory setting.
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影响因子：
2.9
作者：
Maestripieri, Dario;Hoffman, Christy L.;Anderson, George M.;Carter, C. Sue;Higley, James D.
通讯作者：
Higley, James D.
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作者：
Fava, M;Abraham, M;Rosenbaum, JF
通讯作者：
Rosenbaum, JF