Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
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DOI：
10.1371/journal.pone.0062141
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Bezard E
中科院分区：
文献类型：
--
作者：
Camus SM;Blois-Heulin C;Li Q;Hausberger M;Bezard E
到目前为止，对神经精神疾病的实验和临床前研究几乎完全是在实验诱导的动物模型中进行的，很少依赖于在更自然的环境中观察动物的行为学方法。实验室选择的物种是啮齿类动物，而与人类关系更密切的非人类灵长类动物的潜力在很大程度上仍未被发掘。因此，本研究旨在使用无偏见的行为学扫描采样分析、多因素对应分析和等级聚类来研究圈养条件下40只食蟹猴自发的非典型/异常行为的可能性。这项研究确定了五个不同的特征(A到E组)，它们在笼子环境中的几个行为、身体姿势、身体方向、凝视方向和位置上存在显著差异。我们认为，来自低n组(D和E)的动物呈现抑郁和焦虑样症状，这让人想起抑郁和广泛性焦虑症。通过对自发行为和相关参数进行无偏见的行为学观察，突出了个体间的差异，尽管这些与血浆或脑脊液中应激相关激素或单胺水平的差异无关，即符合人类的情况。不需要干预行为测试来区分3个典型的和2个非典型的行为学定义的行为特征，这让人想起某些抑郁和焦虑样的症状。因此，使用无偏见的行为观察可能有助于确定人类精神/行为障碍的动物模型及其最合适的对照组。
To date, experimental and preclinical studies on neuropsychiatric conditions have almost exclusively been performed in experimentally-induced animal models and have only rarely relied upon an ethological approach where animals have been observed in more naturalistic settings. The laboratory species of choice has been the rodent while the potential of more closely-related non-human primates have remained largely underexplored. The present study, therefore, aimed at investigating the possible existence of spontaneous atypical/abnormal behaviours displayed by 40 cynomolgus macaques in captive conditions using an unbiased ethological scan-sampling analysis followed by multifactorial correspondence analysis and a hierarchical clustering. The study identified five distinct profiles (groups A to E) that significantly differed on several behaviours, body postures, body orientations, gaze directions and locations in the cage environment. We suggest that animals from the low n groups (D and E) present depressive-like and anxious-like symptoms, reminiscent of depressive and generalized anxiety disorders. Inter-individual differences were highlighted through unbiased ethological observations of spontaneous behaviours and associated parameters, although these were not associated with differences in plasma or cerebrospinal fluid levels of either stress-related hormones or monoamines, i.e. in accordance with the human situation. No interventional behavioural testing was required to discriminate between 3 typical and 2 atypical ethologically-defined behavioural profiles, reminiscent of certain depressive-like and anxiety-like symptoms. The use of unbiased behavioural observations might, thus, allow the identification of animal models of human mental/behavioural disorders and their most appropriate control groups.
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影响因子：
2.5
作者：
BOLIG, R;PRICE, CS;SUOMI, SJ
通讯作者：
SUOMI, SJ
影响因子：
1.7
作者：
BUIRSKI P;KELLERMAN H;BUIRSKI N
通讯作者：
BUIRSKI N
影响因子：
10.6
作者：
Clarke, AS;Hedeker, DR;Kraemer, GW
通讯作者：
Kraemer, GW
DOI：
10.1073/pnas.93.4.1619
发表时间：
1996-02-20
影响因子：
11.1
作者：
Coplan, JD;Andrews, MW;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
3.4
作者：
Claessens, Sanne E. F.;Daskalakis, Nikolaos P.;van der Veen, Rixt;Oitzl, Melly S.;de Kloet, E. Ronald;Champagne, Danielle L.
通讯作者：
Champagne, Danielle L.