Patterns of periodic holes created by increased cell motility.
Patterns of periodic holes created by increased cell motility.
复制标题
细胞运动增加产生的周期性孔洞模式
DOI：
10.1098/rsfs.2012.0001
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发表时间：
2012-08-06
期刊：
影响因子：
4.4
通讯作者：
Garfinkel A
中科院分区：
文献类型：
--
作者：
Chen TH;Guo C;Zhao X;Yao Y;Boström KI;Wong MN;Tintut Y;Demer LL;Ho CM;Garfinkel A
The reaction and diffusion of morphogens is a mechanism widely used to explain many spatial patterns in physics, chemistry and developmental biology. However, because experimental control is limited in most biological systems, it is often unclear what mechanisms account for the biological patterns that arise. Here, we study a biological model of cultured vascular mesenchymal cells (VMCs), which normally self-organize into aggregates that form into labyrinthine configurations. We use an experimental control and a mathematical model that includes reacting and diffusing morphogens and a third variable reflecting local cell density. With direct measurements showing that cell motility was increased ninefold and threefold by inhibiting either Rho kinase or non-muscle myosin-II, respectively, our experimental results and mathematical modelling demonstrate that increased motility alters the multicellular pattern of the VMC cultures, from labyrinthine to a pattern of periodic holes. These results suggest implications for the tissue engineering of functional replacements for trabecular or spongy tissue such as endocardium and bone.
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影响因子：
3.7
作者：
DIMILLA, PA;QUINN, JA;LAUFFENBURGER, DA
通讯作者：
LAUFFENBURGER, DA
影响因子：
16.6
作者：
Miyazawa, Seita;Okamoto, Michitoshi;Kondo, Shigeru
通讯作者：
Kondo, Shigeru
影响因子：
--
作者：
Maini, PK;McElwain, DLS;Leavesley, DI
通讯作者：
Leavesley, DI
DOI：
10.1073/pnas.0308436101
发表时间：
2004-06-22
影响因子：
11.1
作者：
Garfinkel, A;Tintut, Y;Demer, LL
通讯作者：
Demer, LL
DOI：
10.1098/rstb.1952.0012
发表时间：
1952-01-01
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
TURING, AM
通讯作者：
TURING, AM