Reduced adipose tissue lipoprotein lipase responses, postprandial lipemia, and low high-density lipoprotein-2 subspecies levels in older athletes with silent myocardial ischemia.
Reduced adipose tissue lipoprotein lipase responses, postprandial lipemia, and low high-density lipoprotein-2 subspecies levels in older athletes with silent myocardial ischemia.
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患有无症状心肌缺血的老年运动员的脂肪组织脂蛋白脂肪酶反应降低、餐后脂血症和低高密度脂蛋白2亚种水平。
DOI：
10.1016/0026-0495(94)90244-5
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Goldberg,AP
中科院分区：
文献类型：
--
作者：
Katzel,LI;Busby-Whitehead,MJ;Rogus,EM;Krauss,RM;Goldberg,AP
招募无冠状动脉疾病（CAD）病史的健康老年人（64±1岁，平均±SEM）运动（最大耗氧量[VO2max] > 40 mL/kg/min）正常胆固醇血症男性进行心血管和代谢研究。33%的患者在运动心电图（ECG）上显示无症状的运动诱导ST段下降，与无症状心肌缺血（SI）一致。我们假设高密度脂蛋白（HDL）和餐后甘油三酯（TG）代谢异常可能会增加他们患冠心病的风险。与12名年龄、体脂百分比和VO2max相当的非缺血性对照组相比，13名SI患者的空腹高密度脂蛋白胆固醇（[HDL- c] 41±2v50±2mg /dL，P< .001）和梯度凝胶电泳测量的% hdl2b亚种水平（22±2v34±3，P< .001）降低。两组空腹血浆TG和低密度脂蛋白胆固醇（LDL-C）水平相同。尽管两组在口服葡萄糖耐量试验（OGTT）期间的血浆葡萄糖水平相似，但SI患者的总胰岛素面积更高（P< 0.05）。在食用标准高脂肪食品（680千卡/m2体表面积的配方，其中86%的热量来自脂肪）后，SI男性的餐后血浆TG、乳糜微粒TG和极低密度脂蛋白TG水平和餐后面积较高（P< 0.001）。在逐步多元回归中，餐后TG面积的独立预测因子为空腹TG水平（R2= .76，P< .001）和log10胰岛素面积（R2= .06，P< .02），占TG面积方差的82%。因此，在共变空腹血浆TG水平和总血浆胰岛素面积（ANCOVA）后，两组餐后TG面积的差异不再显著。SI患者肝素后脂肪酶（HL）活性较高（P< 0.02），但肝素后脂蛋白脂肪酶（LPL）活性与对照组相当。SI组空腹腹部脂肪组织（AT） LPL活性高于对照组（P< 0.05），但不随饲喂量变化（0%±12%）。对照组4小时腹部at - lpl活性增加57%±19% （P< 0.05）。餐后TG区与腹部AT-LPL活性变化百分比呈正相关（r=−）。41，P< 0.05)和parin后HL活性（r= .58，P< .005）。因此，年龄较大的正常胆固醇水平的非糖尿病运动男性SI患者胰岛素抵抗增加，肝素后HL活性增加，餐后腹部AT-LPL活性对喂养的反应降低，这与低hdl2亚种水平和餐后脂血症增加有关。这些HDL和餐后TG代谢异常可能增加他们患冠心病的风险。
Healthy older (64 ± 1 years, mean ± SEM) athletic (maximal oxygen consumption [VO2max] > 40 mL/kg/min) normocholesterolemic men with no prior history of coronary artery disease (CAD) were recruited for cardiovascular and metabolic studies. Thirty-three percent had asymptomatic exercise-induced ST segment depression on their exercise electrocardiogram (ECG), consistent with silent myocardial ischemia (SI). We hypothesized that abnormalities in high-density lipoprotein (HDL) and postprandial triglyceride (TG) metabolism may increase their risk for CAD. Compared with 12 nonischemic controls of comparable age, percent body fat, and VO2max, the 13 men with SI had decreased fasting HDL cholesterol ([HDL-C] 41 ± 2v50 ± 2 mg/dL,P< .001) and %HDL2bsubspecies levels as measured by gradient gel electrophoresis (22 ± 2v34 ± 3,P< .001). Fasting plasma TG and low-density lipoprotein cholesterol (LDL-C) levels were the same in both groups. Although plasma glucose levels during an oral glucose tolerance test (OGTT) were similar in both groups, the total insulin area was higher in men with SI (P< .05). After consumption of a standard high-fat maal (680 kcal/m2body surface area of a formula in which 86% of the calories were derived from fat), postprandial plasma TG, chylomicron-TG, and very-low-density lipoprotein (VLDL)-TG levels and postprandial areas were higher in men with SI (P< .001). In stepwise multiple regression, the only independent predictors of postprandial TG areas were fasting TG levels (R2= .76,P< .001) and log10insulin area (R2= .06,P< .02), which accounted for 82% of the variance in TG area. Therefore, after covarying for fasting plasma TG levels and total plasma insulin areas (ANCOVA), the difference in postprandial TG area between groups was no longer significant. The men with SI had higher postheparin hepatic lipase (HL) activity (P< .02), but had postheparin lipoprotein lipase (LPL) activity comparable to that of the control subjects. Fasting abdominal adipose tissue (AT) LPL activity was higher in the men with SI than in the control subjects (P< .05), but it did not change with feeding (0% ± 12%). In contrast, abdominal AT-LPL activity increased by 57% ± 19% at 4 hours (P< .05) in the control subjects. Postprandial TG areas were positively correlated with both the percent change in abdominal AT-LPL activity (r= −.41,P< .05) and postheparin HL activity (r= .58,P< .005). Thus, older normocholesterolemic nondiabetic athletic men with SI have increased insulin resistance, increased postheparin HL activity, and a reduced postprandial response of abdominal AT-LPL activity to feeding, which are associated with low HDL2subspecies levels and increased postprandial lipemia. These abnormalities in HDL and postprandial TG metabolism may increase their risk for CAD.
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影响因子：
3.6
作者：
Wei H;Song B
通讯作者：
Song B
人脂肪组织脂蛋白脂肪酶：测定方法和活性表达的比较 1
DOI：
10.3181/00379727-148-38526
发表时间：
1975
影响因子：
--
作者：
O. Pykälistö;Phillip H. Smith;J. Brunzell
通讯作者：
J. Brunzell
DOI：
10.1016/0005-2760(81)90253-8
发表时间：
1981-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BLANCHE, PJ;GONG, EL;NICHOLS, AV
通讯作者：
NICHOLS, AV
健康人和某些以高脂血症为共同特征的疾病中人体脂肪组织的脂蛋白脂肪酶活性。
影响因子：
--
作者：
B. Persson
通讯作者：
B. Persson
影响因子：
--
作者：
Bachorik,PS;Albers,JJ
通讯作者：
Albers,JJ