Cross-sectional analysis of obesity and serum analytes in males identifies sRAGE as a novel biomarker inversely associated with diverticulosis.
Cross-sectional analysis of obesity and serum analytes in males identifies sRAGE as a novel biomarker inversely associated with diverticulosis.
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DOI：
10.1371/journal.pone.0095232
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fenton JI
中科院分区：
文献类型：
--
作者：
Comstock SS;Lewis MM;Pathak DR;Hortos K;Kovan B;Fenton JI
憩室病可导致憩室炎，一种涉及炎症和其他并发症的结肠疾病。憩室病可由生物、行为或遗传原因引起。然而，憩室病的病因尚不清楚。虽然饮食与憩室病有关，但最近的研究表明其他因素也会影响风险。我们试图确定人体测量或血清标记物与憩室病的存在。为了确定这些关联，在预防性筛查结肠镜检查时招募了126名无症状男性（48-65岁）。进行人体测量，并采集血液进行血清蛋白分析。资料分析采用Logistic回归和因素分析。肥胖个体（BMI >30）患憩室病的可能性是正常体重个体（BMI <25）的7.8倍（CI：2.3-26.3）。腰围的相关性也相似。腰围>45英寸的个体患憩室病的可能性是腰围<38英寸的个体的8.1倍（CI：2.8-23.8）。瘦素也与憩室病呈正相关（OR = 5.5，CI：2.0-14.7）。 低分子量脂联素（LMW，OR = 0.50; CI：0.3-0.8）和晚期糖基化终产物可溶性受体（sCRP，OR = 0.4，CI：0.3-0.7）与憩室病的存在呈负相关。 血清瘦素水平与瘦素或C肽浓度无关。高BMI、腰围、瘦素和C肽的模式增加了憩室病的几率，而高血清瘦素和低分子量脂联素的模式降低了憩室病的几率。憩室病和人体测量学或血清标志物之间的关联可能阐明憩室病的起源，并可能使医生确定个人的风险憩室炎。
Diverticulosis can lead to diverticulitis, a colon condition involving inflammation and other complications. Diverticulosis can result from biological, behavioral, or genetic causes. However, the etiology of diverticulosis is unknown. Although diet is associated with diverticulosis, recent studies suggest other factors influence risk. We sought to identify anthropometric or serum markers that were associated with the presence of diverticulosis. To determine these associations, 126 asymptomatic men (48–65 yr) were recruited at the time of preventative screening colonoscopy. Anthropometric measures were taken, and blood was collected for serum protein analysis. Data were analyzed by logistic regression and factor analysis. Obese individuals (BMI >30) were 7.8 (CI: 2.3–26.3) times more likely than normal weight (BMI <25) individuals to have diverticulosis. The relationship was similar for waist circumference. Individuals with a waist circumference >45 inches were 8.1 (CI: 2.8–23.8) times more likely to have diverticulosis than those with a waist circumference <38 inches. Leptin was also positively associated with diverticulosis (OR = 5.5, CI: 2.0–14.7). Both low molecular weight adiponectin (LMW, OR = 0.50; CI: 0.3–0.8) and the soluble receptor for advanced glycation end products (sRAGE, OR = 0.4, CI: 0.3–0.7) were inversely related to the presence of diverticulosis. sRAGE levels were not correlated with leptin or C-peptide concentrations. The pattern of high BMI, waist circumference, leptin and C-peptide increased the odds of diverticulosis while the pattern of high levels of sRAGE and LMW adiponectin decreased the odds of diverticulosis. Associations between diverticulosis and anthropometric or serum markers may elucidate the origins of diverticulosis and may enable physicians to identify individuals at risk for diverticulitis.
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DOI：
10.1007/s004649901007
发表时间：
1999-04-01
期刊：
SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES
影响因子：
--
作者：
Köhler, L;Sauerland, S;Neugebauer, E
通讯作者：
Neugebauer, E
影响因子：
12.6
作者：
Peery, Anne F.;Sandler, Robert S.;Baron, John A.
通讯作者：
Baron, John A.
影响因子：
5.8
作者：
Choi, Kyung Mook;Han, Kyung Ah;Min, Kyung Wan
通讯作者：
Min, Kyung Wan
影响因子：
7.1
作者：
Martin, ASG;Obin, MS
通讯作者：
Obin, MS
影响因子：
3.2
作者：
Kopylov, Uri;Ben-Horin, Shomron;Carter, Dan
通讯作者：
Carter, Dan