Dataset on the response of Hut78 cells to novel rexinoids.
Dataset on the response of Hut78 cells to novel rexinoids.
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DOI:
10.1016/j.dib.2018.09.012
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发表时间:
2018-10
期刊:
影响因子:
1.2
通讯作者:
Marshall PA
中科院分区:
文献类型:
--
作者:
Hackney Price J;Hanish BJ;Wagner CE;Kaneko I;Jurutka PW;Marshall PA
This article presents the experimental data supporting analysis of differential gene expression of human cutaneous T cell lymphoma (CTCL) cell culture cells (Hut78) treated with bexarotene or a variety of rexinoids, in conjunction with “A Novel Gene Expression Analytics-based Approach to Structure Aided Design of Rexinoids for Development as Next-Generation Cancer Therapeutics” (Hanish et al. 2018). Data presented here include microarray gene expression analysis of a subset of genes. A novel method for analyzing gene expression in the context of a model of ligand mechanism, called the Divergence Score, is described. Analysis to identify the presence of potential retinoid response elements in putative promoter regions of the study genes is also presented.
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