Dataset on the response of Hut78 cells to novel rexinoids.

Dataset on the response of Hut78 cells to novel rexinoids.
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DOI:
10.1016/j.dib.2018.09.012
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发表时间:
2018-10
期刊:
影响因子:
1.2
通讯作者:
Marshall PA
Marshall PA
中科院分区:
其他
文献类型:
--
作者:
Hackney Price J;Hanish BJ;Wagner CE;Kaneko I;Jurutka PW;Marshall PA

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本文提供了支持分析用贝沙罗汀或各种rexinoids处理的人皮肤T细胞淋巴瘤(CTCL)细胞培养细胞(Hut 78)的差异基因表达的实验数据,以及“一种基于新型基因表达分析的Rexinoids结构辅助设计方法,用于开发下一代癌症治疗药物”(Hanish et al. 2018)。这里提供的数据包括基因子集的微阵列基因表达分析。描述了一种新的方法,用于分析基因表达的背景下的配体机制的模型,称为分歧分数。分析,以确定潜在的类维生素A反应元件的存在下,在推定的启动子区域的研究基因。
This article presents the experimental data supporting analysis of differential gene expression of human cutaneous T cell lymphoma (CTCL) cell culture cells (Hut78) treated with bexarotene or a variety of rexinoids, in conjunction with “A Novel Gene Expression Analytics-based Approach to Structure Aided Design of Rexinoids for Development as Next-Generation Cancer Therapeutics” (Hanish et al. 2018). Data presented here include microarray gene expression analysis of a subset of genes. A novel method for analyzing gene expression in the context of a model of ligand mechanism, called the Divergence Score, is described. Analysis to identify the presence of potential retinoid response elements in putative promoter regions of the study genes is also presented.
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