Macrolide-Resistant and Macrolide-Sensitive Mycoplasma pneumoniae Pneumonia in Children Treated Using Early Corticosteroids.
Macrolide-Resistant and Macrolide-Sensitive Mycoplasma pneumoniae Pneumonia in Children Treated Using Early Corticosteroids.
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DOI：
10.3390/jcm10061309
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发表时间：
2021-03-22
影响因子：
3.9
通讯作者：
Lee KY
中科院分区：
文献类型：
--
作者：
Han HY;Park KC;Yang EA;Lee KY
我们发现，在韩国五次大流行期间，早期皮质类固醇治疗对降低发病率是有效的。我们评估了2019年7月至2020年2月期间接受早期皮质类固醇治疗的56名儿童的临床和实验室参数，这些儿童由大环内酯耐药肺炎支原体(M。肺炎)或大环内酯敏感肺炎支原体引起。所有受试者的聚合酶链式反应和血清学检测均呈双重阳性，并在入院后24-36h内接受了皮质类固醇治疗。在23S rRNA的V区发现了2063、2064和2067残基的点突变。平均年龄6.8岁，男女之比为1.2：1(31：25)。大多数受试者患有大环内酯类耐药肺炎支原体(73%)，所有突变株都有A2063G转换。在接受早期剂量调整的皮质类固醇治疗的肺炎支原体耐药组和敏感组之间，临床和实验室参数没有显著差异。对于发烧持续48小时或在随访时乳酸脱氢酶浓度升高的患者，可能需要更大剂量的类固醇治疗，尽管常规剂量的类固醇治疗。
We have found that early corticosteroid therapy was effective for reducing morbidity during five Korea-wide epidemics. We evaluated the clinical and laboratory parameters of 56 children who received early corticosteroid treatment for pneumonia that was caused by macrolide-resistant Mycoplasma pneumoniae (M. pneumoniae) or macrolide-sensitive M. pneumoniae between July 2019 and February 2020. All subjects had dual positive results from a PCR assay and serological test, and received corticosteroids within 24–36 h after admission. Point mutation of residues 2063, 2064, and 2067 was identified in domain V of 23S rRNA. The mean age was 6.8 years and the male:female ratio was 1.2:1 (31:25 patients). Most of the subjects had macrolide-resistant M. pneumoniae (73%), and all mutated strains had the A2063G transition. No significant differences in clinical and laboratory parameters were observed between macrolide-resistant and macrolide-sensitive M. pneumoniae groups that were treated with early dose-adjusted corticosteroids. Higher-dose steroid treatment may be needed for patients who have fever that persists for >48 h or increased biomarkers such as lactate dehydrogenase concentration at follow-up despite a usual dose of steroid therapy.
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DOI：
10.3390/pathogens10010031
发表时间：
2021-01-02
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Betti C;Camozzi P;Gennaro V;Bianchetti MG;Scoglio M;Simonetti GD;Milani GP;Lava SAG;Ferrarini A
通讯作者：
Ferrarini A
影响因子：
--
作者：
Lee E;Cho HJ;Hong SJ;Lee J;Sung H;Yu J
通讯作者：
Yu J
影响因子：
2.5
作者：
Lu, Aizhen;Wang, Chuankai;Qian, Liling
通讯作者：
Qian, Liling
影响因子：
5.6
作者：
Lee KY
通讯作者：
Lee KY
影响因子：
11.8
作者：
Hong KB;Choi EH;Lee HJ;Lee SY;Cho EY;Choi JH;Kang HM;Lee J;Ahn YM;Kang YH;Lee JH
通讯作者：
Lee JH